12 April 2022: Letter To Editor
Pancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas TransplantationKarolina Kędzierska-Kapuza1ABCDEF*, Grzegorz Witkowski 1BDE, Katarzyna Baumgart-Gryn2E, Marek Durlik1ABG
Ann Transplant 2022; 27:e935863
ABSTRACT: Arterial and venous thrombosis of pancreatic allografts is a rare complication in the late post-transplantation period. In addition to traditional thrombosis risk factors, SARS-CoV-2 infection predisposes patients to thrombotic diseases in both arterial and venous vessels. Transplant patients with a history of COVID-19 should be carefully monitored for arterial embolism and graft vein thrombosis. Early detection of this complication in patients after transplantation allows a chance to save the organ. Thromboprophylaxis with low molecular weight heparin is of great importance.
Keywords: COVID-19, Embolism and Thrombosis, Pancreas Transplantation, Allografts, Diabetes Mellitus, Type 1, Humans, Pancreas, Thrombosis
Transplant patients who have experienced COVID-19 should be carefully monitored for the occurrence of graft arterial and vein embolism. Early detection of these complications in patients after organ transplantation gives an opportunity to save the organ. Thromoprophylaxis with low molecular weight heparin is highly important and should be continued in high-risk patients (obese, with persistent d-dimer levels >1000) for a minimum of 2 weeks (preferably 4–6 weeks) after reaching the convalescent status.
FiguresFigure 1. (A–C) 3D vascular reconstructions of Computed Tomography. A, B – Arterial phase. C – Venous phase. The marks show the localization of pancreatic graft. It is not visible because of the absence of blood flow. (D–G) Images from gastroduodenoscopy. Marks show the necrosis of the mucosa of transplanted duodenum with central ulceration.
1. Haldane V, De Foo C, Abdalla SM, Health systems resilience in managing the COVID-19 pandemic: Lessons from 28 countries: Nat Med, 2021; 27; 964-80
3. Goldman IA, Ye K, Scheinfeld MH, Lower-extremity arterial thrombosis associated with COVID-19 is characterized by greater thrombus burden and increased rate of amputation and death: Radiology, 2020; 297; E263-69
4. Wang T, Chen R, Liu C, Attention should be paid to venous thromboembolism prophylaxis in the management of COVID-19: Lancet Haematol, 2020; 7; e362-63
5. Kędzierska-Kapuza K, Zielińska D, Matejak-Górska M, Durlik M, The course of SARS-CoV-2 in a patient after a recent kidney transplant: A literature review on COVID-19 therapy: Transplant Proc, 2021; 53; 1194-201
6. Tantisattamo E, Dafoe DC, Ferrey AJ, Kidney allograft infarction associated with transplant renal artery stenosis in a COVID-19 kidney transplant recipient: Clin Nephrol Case Stud, 2021; 26(9); 93-104
7. Xu JJ, Samaha D, Mondhe S, Renal infarct in a COVID-19-positive kidney-pancreas transplant recipient: Am J Transplant, 2020; 20; 3221-24
14 Sep 2023 : Case reportIntrahepatic Venous Collateral Circulation and Reverse Blood Flow After Main Hepatic Vein Obstruction: A Ca...
Ann Transplant In Press; DOI: 10.12659/AOT.941521
12 Sep 2023 : Original articleThree-Dimensional Printing of Polycaprolactone/Nano-Hydroxyapatite Composite Scaffolds with a Pore Size of ...
Ann Transplant In Press; DOI: 10.12659/AOT.940365
04 Sep 2023 : Original articleAnalysis of Anxiety and Influencing Factors in Kidney Transplant Recipients and General Public During the C...
Ann Transplant In Press; DOI: 10.12659/AOT.941489
Most Viewed Current Articles
24 Aug 2021 : Review articleNormothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives
Ann Transplant 2021; 26:e931664
26 Jan 2022 : Review articleRecurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models
Ann Transplant 2022; 27:e934924
29 Dec 2021 : Original articleEfficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...
Ann Transplant 2021; 26:e933588