Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

15 December 2004

Biological Effects of Bone Marrow In Transplanted Limb – A Review

M Durlik, W L Olszewski

Ann Transplant 2004; 9(4): 26-33 :: ID: 12978

Abstract

Transplantation of a vascularized limb should be considered as a double graft: composite parenchymatous non-lymphoid tissue (skin, subcutaneous tissue, muscles, nerves and bones in a block) and bone marrow (BM) tissue. Ready-to-function BM releases mature and precursor cells migrating to the recipient tissues immediately after transplantation. Donor BM-derived cells home to recipient BM cavities and lymphoid organs (LO) and to lesser extent to the non-lymphoid tissues. Interestingly, no acute and subacute graft-versus-host reaction develops. Cellular microchimerism is detected with the presence of donor cells in recipient tissues, at least as long as the transplanted limb is not rejected. Free donor DNA appears in high concentrations in recipient tissues at the time of rejection. The biological significance of the cellular and DNA microchimerism is not clear. Slight prolongation of limb and free-flap skin grafts survival time may be attributed to microchimerism. The beneficial and unwanted effects of transplanted BM tissue should be taken into consideration in the clinical limb transplantation programme. Long-term experimental and clinical observations will allow to draw more clinically applicable conclusions. Abbreviations used in this review: BM: bone marrow, BMC: bone marrow cells, BMTx: bone marrow transplantation, il-BMTx: in limb-bone marrow transplantation, iv-BMCTx: intravenous isolated bone marrow cell transplantation, MLN: mesenteric lymph node, SPL: spleen, LO: lymphoid organs, PHA: phytohemagglutinin, ConA: concavalin A, PWM: pokeweed mitogen, CsA: cyclosporin A, TBI: total body irradiation.

Keywords: Limb Transplantation, Bone Marrow Vascularized Graft, Homing, microchimerism

Add Comment 0 Comments

In Press

Original article  

Engraftment Syndrome in Autologous Hematopoietic Stem Cell Transplant Patients: Incidence, Associated Risk ...

Ann Transplant In Press; DOI: 10.12659/AOT.944043  

Original article  

Comparative Study of Acute Kidney Injury in Liver Transplantation: Donation after Circulatory Death versus ...

Ann Transplant In Press; DOI: 10.12659/AOT.944077  

Original article  

Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Ann Transplant In Press; DOI: 10.12659/AOT.944245  

Original article  

Kidney After Lung Transplants or Combined Kidney–Lung Transplantation: A Single-Center Retrospective Cohort...

Ann Transplant In Press; DOI: 10.12659/AOT.944049  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,404

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

22 Nov 2022 : Original article   9,258

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

12 Jan 2022 : Original article   8,843

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

15 Mar 2022 : Case report   6,648

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358