Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

01 July 2004

Weight increase during machine perfusion may be an indicator of organ and, in particular, vascular damage.

C H Wilson, M A Gok, B K Shenton, S Balupuri, A J Gupta, J Asher, D Talbot

Ann Transplant 2004; 9(2): 31-32 :: ID: 142786

Abstract

OBJECTIVES: Hypothermic machine perfusion preservation has been shown toimprove the outcome of renal grafts from non-heartbeating donors. We have noticed that organs gain avariable amount of weight during perfusion. METHODS: All grafts, whether used or discarded, were assessedwith respect to their weight gain. Primary outcome measures were the results of viability testing. Secondaryoutcomes were early transplant variables including incidence and duration of delayed graft function andhistological examination of protocol graft biopsies. RESULTS: Weight increase data was available on 97grafts. There were no significant differences in weight gain between kidneys used and discarded (17%vs 20%). 14 patients received grafts which gained over 30% of their initial retrieval weight. There wereno significant differences in secondary outcome measures between this group of recipients and patientswho had received less "waterlogged" kidneys. Histological changes including endothelial inflammationand oedema were observed. CONCLUSIONS: Kidney grafts which have gained over 30% of weight on hypothermicmachine perfusion preservation can be transplanted successfully. Complex interactions between the periodof warm ischaemia, in situ flushing, perfusion pressures and perfusate probably lead to the phenomenonof excessive graft weight gain.

0 Comments

Most Viewed Current Articles

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358