Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

16 June 2006

The Future of Organ Transplantation

Marilia Cascalho, Brenda M Ogle, Jeffrey L Platt

Ann Transplant 2006; 11(2): 44-47 :: ID: 496984

Abstract

No challenge in medicine can be more urgent than the devising of new strategies for replacing organs. The need for organ replacement not only exceeds by far the supply of organs available for transplantation, the need is likely to increase dramatically. The induction of tolerance to spare transplanted organs and the use of animal organs, i.e. xenotransplantation, could help address this problem but neither appears close to application. Here we discuss a strategy involving the sequential generation of pleuripotent stem cells, formation of human organs in an adoptive xenogeneic host, the harvesting of human cells, tissues or organs from that host and implantation into the individual from whom the stem cells were obtained as one potential way to generate histocompatible organs. We discuss as well the promise, limitations and uncertainties of these steps. This approach, while speculative and perhaps unlikely, may lead to development of further new technologies and insights, the pursuit of which could provide new approaches to replacing organ function.

Keywords: Organ Transplantation, Xenotransplantation, Stem Cells, Pleuripotent Stem Cells, angiogenesis, cloning

Add Comment 0 Comments

In Press

Original article  

Post-Donation Regret and Anxiety Among Family Living Liver Donors: The Mediating Roles of Family Relationsh...

Ann Transplant In Press; DOI: 10.12659/AOT.944176  

Original article  

Effect of the Organ Donation Quality System on Donation Activity of Warsaw Hospitals

Ann Transplant In Press; DOI: 10.12659/AOT.943520  

Original article  

Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic S...

Ann Transplant In Press; DOI: 10.12659/AOT.943688  

Original article  

Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A Unit...

Ann Transplant In Press; DOI: 10.12659/AOT.943994  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,171

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article   8,611

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article   8,587

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report   6,458

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358