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06 January 1997

Immunologic barriers in pig-to-primate cardiac xenotransplantation

John H Artrip, Pawel Kwiatkowski, Robert E Michler, Silviu Itescu

Ann Transplant 1997; 2(1): 5-11 :: ID: 497117

Abstract

Clinical heart transplantation using human cadaver organs remains the most effective therapy for end-stage heart disease; however, the severe shortage of organs has led to alternative strategies utilizing non-human organs (xenografts). In human allotransplantation, the predominant antigenic differences between donor and recipient are confined to the major histocompatibility and blood group antigens. In contrast, a xenograft is able to express a variety of antigens, in addition to the major histocompatibility and blood group antigens, which are not expressed by human cells and can elicit anti-xenograft immunity in human recipients.

Keywords: discordant xenotransplantation, anti-Galantibodies, delayed rejection, T lymphocytes, transgenic animals

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358