09 June 2000
Post-TransplanIt Immune Serological Markers May Be Predictive of Chronic Rejection
Ronald H KermanAnn Transplant 2000; 5(2): 24-28 :: ID: 497522
Abstract
Chronic rejection isan important cause ofgraft dysfunction and loss after the first posttransplant year [1].Two working hypotheses have evolved to explainthe etiology of the process. The first is an antigen-dependent phenomenon influenced by early immunological injury whereas the second is related to alloantigen-independent events contributing to progressive chronic graft dysfunction [2,3]. Our study, reported herein, focuses on the antigen-dependent aspects of chronic rejection. Several hypotheses have been proposed to explain the immunologic basis of chronic rejection. The first involvesrecurrent episodes of acute rejection that lead to protracted tissue damage and scarring [2,3].An alternative immune hypothesis to explain chronic rejection is that the immune-regulatory mechanisms that prevent acute rejection playa role in chronic rejection by supporting B cell responses and antibody formation. Therefore, chronic rejection may be a predominantly antibody- mediated form of graft damage..
Keywords: post-transplant antibody, chronic rejection
In Press
Original article
Steroid Use in ABO-Incompatible Kidney Transplants: Withdrawal vs MaintenanceAnn Transplant In Press; DOI: 10.12659/AOT.947747
Original article
Intra-Arterial Contrast-Enhanced Ultrasound for Transcatheter Thrombolysis in Post-Transplant Hepatic Arter...Ann Transplant In Press; DOI: 10.12659/AOT.947500
Original article
Early Atropine Protocol Enhances Dobutamine Stress Echocardiography in End-Stage Liver Disease: A Practical...Ann Transplant In Press; DOI: 10.12659/AOT.950166
Most Viewed Current Articles
15 Aug 2023 : Review article 7,349
Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ TransplantationDOI :10.12659/AOT.939750
Ann Transplant 2023; 28:e939750
03 Jan 2023 : Original article 7,212
Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...DOI :10.12659/AOT.938467
Ann Transplant 2023; 28:e938467
16 May 2023 : Original article 7,034
Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...DOI :10.12659/AOT.939258
Ann Transplant 2023; 28:e939258
28 May 2024 : Original article 6,633
Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...DOI :10.12659/AOT.943281
Ann Transplant 2024; 29:e943281