Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

19 December 2001

No Evidence for Participation of Non-Adrenergic Non-Cholinergic Subtances in Brain Death-Related Hemodynamic Deterioration of the Feline Potential Heart Donor

GJ. Brandon Bravo Bruinsma, J.J. Bredee, T. J.C. Ruigrok, Van Echteld, J. H.H. Thijssen

Ann Transplant 2001; 6(4): 43-47 :: ID: 497839


Objective: The onset of brain death (BD) is associated with a hyperdynamic cardiovascular response caused by the acute sympathetic release of catecholamines. This is followed by progressive hemodynamic deterioration which may preclude heart donation for transplantation. The mechanism of the hemodynamic collapse is not fully understood. Changes in plasma concentrations of non-adrenergic non-cholinergic (NANC) substances. neuropeptide-Y (NP-Y. a vasoconstrictor) and the vasodilators calcitonin gene-related peptide (CGRP) and substance P (SP). were studied in relation to BD-related hemodynamic alterations. Materials and Methods: Cats (6 BD and 6 controls (C» were studied for 6 h. Heart rat~ (HR) and mean arterial pressure (MAP) were monitored. BD was induced at t = 0 min. At t = -5, 15.60, 180 and 360 min. 5 ml arterial blood samples were taken. The plasma was collected and analyzed. The correlations between MAP and NANC levels were calculated. Results: In the BD cats a maximal and significant increase in HR and MAP was observed at t = 2 min. HR returned to basal levels at t = 20 min and remained at that level. However. MAPdeteriorated progressively to 53:t8 mmHg (p 0.00 I vs C) at / =360 min. NP-Yhad increased from 59.7:t2.5 to 110:t20.2 pmoVI (p 0.05 vsC) at t = 15 min, had returned to basal value at t =60 min and remained at that level. CGR Plevels were lower and SP levels did not change vs C but both showed a trend towards higher levels at t =360 min. The correlations between MAP and NP- Y, CGRP and SP appeared to be not significant. Conclusion: No evidence for participation of NANC substances could be demonstrated in brain death-related hemodynamic deterioration of the feline potential heart donor

Keywords: Brain Death, hemodynamic response, Neuropeptides

Add Comment 0 Comments

512 0

In Press

10 Nov 2023 : Original article  

Effects of Preservation of Donor Liver Gastroduodenal Artery on Post-Transplant Biliary Complications in 18...

Ann Transplant In Press; DOI:  

07 Nov 2023 : Original article  

Allogeneic Hematopoietic Stem Cell Transplantation Can Improve Prognosis of Extramedullary Infiltration Pos...

Ann Transplant In Press; DOI:  

06 Nov 2023 : Original article  

Clinical Outcomes of Administration of Rituximab for Desensitization in Liver Transplant Patients with Pref...

Ann Transplant In Press; DOI:  

06 Nov 2023 : Original article  

Short-Term Monitoring of Graft Regeneration in Partial Liver Transplantation Recipients

Ann Transplant In Press; DOI:  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358