Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

30 November 2002

Predicting the Grade of Banff 97 Classification of Chronic Allograft Nephropathy Based on Examination of Graft Dysfunction (a Preliminary Report)

O Schück, O Viklický, L Voska, S Vítko, V Teplan, J Lácha, A Jabor, J Skibová, M Štollová

Ann Transplant 2003; 8(3): 5-7 :: ID: 7519

Abstract

Objectives: Progression of chronic allograft nephropathy (CAN) is associated with a progressive decrease in graft function. Prediction of the Banff CAN grade on the basis of correlation between the grade of histological changes and Scr is difficult because of the big spread of individual values. This study sought to predict the Banff CAN grade based on Scr, Ccr and proteinuria using ROC analysis. Methods: Graft protocol biopsy and functional testing (Scr, Ccr and proteinuria) were performed in 77 subjects (43 men, 34 women, mean age 48.4±12.8 years) at 33.8±1.0 months after their first renal transplantation. Immunosuppression was provided with the triple combination of cyclosporin A, prednisone and azathioprine (or mycophenolate mofetil). Statistical evaluation was performed using receiver-operating curve (ROC) analysis. The cut-off value of the Banff CAN score was set at 1. Results: The mean values and SD of the investigated functional parameters in study subjects were as follows: Scr = 201.5 (±100.0) µmol/l Ccr = 48.1 (±21.2) ml/min/1.73 m2, proteinuria = 0.89 (±1.96) g/24 h. ROC analysis showed the highest AUC (±SEM) for Scr 0.806 (±0.063). The respective values were 0.790 (±0.053) for Ccr and 0.643 (±0.075) for proteinuria. The AUC (area under the ROC curve) for Scr was significantly higher (P275 µmol/l and Ccr

Add Comment 0 Comments

In Press

Original article  

Outcomes of Combined Liver-Kidney Transplantation in Polycystic Liver and Kidney Disease

Ann Transplant In Press; DOI: 10.12659/AOT.947639  

Most Viewed Current Articles

03 Jan 2023 : Original article   6,893

Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...

DOI :10.12659/AOT.938467

Ann Transplant 2023; 28:e938467

15 Aug 2023 : Review article   6,848

Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ Transplantation

DOI :10.12659/AOT.939750

Ann Transplant 2023; 28:e939750

16 May 2023 : Original article   6,597

Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...

DOI :10.12659/AOT.939258

Ann Transplant 2023; 28:e939258

28 May 2024 : Original article   5,949

Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...

DOI :10.12659/AOT.943281

Ann Transplant 2024; 29:e943281

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358