Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

28 December 2007

The influence of donor-related factors on the frequency of acute cellular rejection by the recipient in the first year following heart transplantation

Małgorzata Sobieszczańska – Małek, Tomasz Zieliński, Jerzy Korewicki

Ann Transplant 2007; 12(4): 38-43 :: ID: 764933

Abstract

Background: This study was an attempt to identify donor-related factors influencing the frequency of acute cellular rejection episodes in cardiac transplant recipients in the first year following transplantation.
Material/Methods: The study encompassed 76 patients (14 women and 62 men) aged 6–68 years, mean 47.8±16.3, who received a cardiac transplant at the Institute of Cardiology in Warsaw between 2001–2005. The period of observation was from day 7 after transplantation (the day of the first biopsy by protocol) to the end of the first year. Follow-up at the outpatient department included physical examination, echocardiography, blood biochemistry and determination of circulating levels of immunosuppressive drugs. Endomyocardial biopsies were obtained and evaluated according to ISHLT criteria. The study was conducted according to the following biopsy schedule: every 7 days in the first month, every 14 days in the second, and every three months from month three to the end of the first year. The frequency of acute cellular rejection was assessed along with potential donor-related factors (age, gender, donor cause of death). The study protocol was approved by the Local Bioethics Committee of the Institute of Cardiology. Comparative statistical analysis was conducted retrospectively using the Mann- Whitney and Kruskal-Wallis tests.
Results: A total of 39 abnormal biopsies were found (degree 2 and 3 ISHLT) among the 750 biopsies performed (5.2%). No significant differences were found in the number of acute cellular rejection episodes in relation to treatment protocol and blood cyclosporine concentration in the studied period. Acute cellular rejection was occured significantly more frequently when intracerebral hemorrhage was the donor’s cause of death (p<0.0131) and showed a tendency to occur more frequently when the donor was female (p<0.0611). The effects of donor age, blood type and duration of ischemia were not significant.
Conclusions: Significantly more episodes of acute cellular rejection occur in recipients of hearts from donors who died from intracerebral hemorrhage. A trend towards more frequent episodes of acute cellular rejection appears when the donor was female.

Keywords: cardiac transplantation, Acute Cellular Rejection, Donor

Add Comment 0 Comments

In Press

Original article  

The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival Afte...

Ann Transplant In Press; DOI: 10.12659/AOT.945249  

Original article  

Biopsychosocial Effects of Donor Traits on Heart Transplant Recipients

Ann Transplant In Press; DOI:  

Clinical Research  

Ten-Year Retrospective Analysis of Continuous Renal Replacement Therapy in Burn Patients: Impact on Surviva...

Ann Transplant In Press; DOI:  

Original article  

Factors Influencing Stress Disorders in Intensive Care Unit (ICU) Patients After Liver Transplantation: A C...

Ann Transplant In Press; DOI: 10.12659/AOT.944320  

Most Viewed Current Articles

05 Apr 2022 : Original article   13,113

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

22 Nov 2022 : Original article   10,260

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

12 Jan 2022 : Original article   9,611

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

15 Mar 2022 : Case report   7,271

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358