31 December 2003
Ann Transplant 2004; 9(1): 72-73 :: ID: 8009
Increasing amounts of older recipients are listed for transplantation. Several clinical trials have therefore been initiated recently using age-adapted immunosuppressive regimens. Preliminary data in an “old-for-old” kidney transplant program at our center suggest that the approach favouring reduced immunosuppression in aged subjects might not be the best choice. We performed an experimental study to investigate the effects of donor and recipient age on renal allograft outcome and age associated alterations of the immune response. Modifications of the immune response in older recipients were associated with increased amounts of memory and alloreactive T-cells and an altered cytokine response. Recipient age dependent immune responses contributed to an acceleration of chronic graft deterioration, so that recipient age may need to be considered as a separate and independent risk factor. Although our experimental data need to be confirmed clinically, they suggest a modified and age-adapted immunosuppression in elderly recipients during the early posttransplant period.
06 Feb 2024 : Case reportSuccessful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal ...
Ann Transplant In Press; DOI: 10.12659/AOT.941881
12 Feb 2024 : Original articleNo Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...
Ann Transplant In Press; DOI: 10.12659/AOT.942767
Most Viewed Current Articles
05 Apr 2022 : Original articleImpact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original articleRisk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original articleLong-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...
Ann Transplant 2022; 27:e937988