Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

31 December 2003

Modifications of Immune Regulations with Increasing Donor & Recipient Age

Stefan Tullius, Andreas Pascher, Johann Pratschke, Peter Neuhaus

Ann Transplant 2004; 9(1): 72-73 :: ID: 8009

Abstract

Increasing amounts of older recipients are listed for transplantation. Several clinical trials have therefore been initiated recently using age-adapted immunosuppressive regimens. Preliminary data in an “old-for-old” kidney transplant program at our center suggest that the approach favouring reduced immunosuppression in aged subjects might not be the best choice. We performed an experimental study to investigate the effects of donor and recipient age on renal allograft outcome and age associated alterations of the immune response. Modifications of the immune response in older recipients were associated with increased amounts of memory and alloreactive T-cells and an altered cytokine response. Recipient age dependent immune responses contributed to an acceleration of chronic graft deterioration, so that recipient age may need to be considered as a separate and independent risk factor. Although our experimental data need to be confirmed clinically, they suggest a modified and age-adapted immunosuppression in elderly recipients during the early posttransplant period.

Add Comment 0 Comments

In Press

06 Feb 2024 : Case report  

Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal ...

Ann Transplant In Press; DOI: 10.12659/AOT.941881  

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358