Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

New tools for defining immune stability in long-term recipients of kidney allograft

J Soulillou

Ann Transplant 2009; 14(1): 12-12 :: ID: 880239


The study of biological correlates associated with state of operational acceptance of mismatched kidney grafts years after of total interruption of immunosuppressive drugs on one side, and the growing information concerning biomarkers associated with chronic rejection may contribute to a better understanding of the status of "stable patients" years following transplantation. This understanding is crucial for guiding eventual minimalisation on weaning of immunosuppressive drugs. Recently, our laboratory has described several biological correlates with immunosuppressive drug free operational acceptance of kidney graft, including phenotypes and transcriptional alterations. Similarly, we have described a series of blood biomarkers increased (TLR4, Trib1, PSMB10) or decreased (granzyme B) in the blood of patients with chronic active rejection associated with DSA. Using these acceptance or rejection biomarkers, we screened a cohort of 164 patients presenting a highly stable clinical status at more than five years after transplantation. We show that these patients do not express the rejection associated set of biomarkers. However, according to the stringency of the analysis, few patients, of these patients under dual therapy, exhibit the operational acceptance signature (<5%). Longer follow up of these stable patients also show that a minority of them (~10%) have degraded their function with time. Grafts biopsies of these patients did not evidence chronic rejection symptom, excepted in one case but show aspecific lesions (toxicity, relapse or LAN). Despite this late degradation was not related to chronic rejection, DNAchips performed on these patients at the time of their highly stable status discriminated this outcome suggesting that an "aspecific" infl ammation status can be monitored. Collectively we hope that these data will set more scientific bases for protocols aimed at weaning CNI or other immunosuppressive drugs.

Keywords: immunosuppressive drugs, Transplantation

Add Comment 0 Comments

In Press

Original article  

Post-Donation Regret and Anxiety Among Family Living Liver Donors: The Mediating Roles of Family Relationsh...

Ann Transplant In Press; DOI: 10.12659/AOT.944176  

Original article  

Effect of the Organ Donation Quality System on Donation Activity of Warsaw Hospitals

Ann Transplant In Press; DOI: 10.12659/AOT.943520  

Original article  

Clonal Hematopoiesis-Associated Gene Mutations Affect Acute Graft-Versus-Host Disease After Hematopoietic S...

Ann Transplant In Press; DOI: 10.12659/AOT.943688  

Original article  

Impact of Recipient and Donor Body Mass Index on Survival Outcomes After Intestinal Transplantation: A Unit...

Ann Transplant In Press; DOI: 10.12659/AOT.943994  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,171

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article   8,611

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article   8,587

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report   6,458

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358