Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Simultaneous total pancreatectomy with islets autotransplantation – one year follow-up

K Pawelec, A Berman, Z Wierzbicki, A Kwiatkowski, A Chmura, J Trzebicki, M Wszoła, M Krajewska, A Niebisz, W Karnafel, P Fiedor

Ann Transplant 2009; 14(1): 24-24 :: ID: 880285

Abstract

Background: Enzyme supplementation and analgesia is a basic treatment in patients with chronic pancreatitis with pain syndrome. Absence of pain relief after conventional treatment and endosurgery should be an indication for surgery. Islets autotransplantation performed simultaneously with pancreatectomy gives a chance to prevent iatrogenic diabetes or to alleviate its course.
Material/Methods: Pancreas was perfused with collagenase/protease solution and then digested in Riccordi chamber. Procured suspension of islets and exocrine tissue was infused into the liver through the portal vein. One year follow-up protocol involved C-peptide level, insulin requirement, HbA1c and quality of life assessment.
Results: Complete pain relief has been achieved after pancreatectomy. Although insulin-independence has not been achieved, C-peptide level is 0.6 ng/mL and insulin dosage from 14 to 20 units/day indicate partial islets function with glucose level between 60 up to 180 mg%. No acute insulin treatment complication has been observed. HbA1c is maintained <6.5 mg%. Patient has estimated his quality of life better then it was expected before the surgery.
Conclusions: Islet autotransplantation should be performed in every case of
non-diabetic patient with chronic pancreatitis qualified for pancreatectomy.
Islet autotransplantation is a safety surgical procedure and may protect from
iatrogenic diabetes in patients after total pancreatectomy.

Keywords: case report, clinical outcome

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358