Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Liver transplantation as a treatment of hepatoblastoma – single center experience

H Ismail, D Broniszczak, P Kaliciński, B Bagińska-Dembowska, D Perek, P Kluge, A Kościesza, A Lembas

Ann Transplant 2009; 14(1): 27-27 :: ID: 880297


Background: Hepatoblastoma (HBL) is the most common primary hepatic tumour in children. The aim of the study was retrospective analysis of the type of management and its results in children with HBL in our centre for over the last 19 years.
Material/Methods: Between 1990 and 2008 there were 44 children with  hepatoblastoma treated in our centre. All patients were treated with various protocols of chemotherapy. In 32 children partial resection of liver was  performed, in 9 with unresectable tumour liver - transplantation. Among them there were 2 pts with pulmonary metastases cleared by chemotherapy, and 2 with local tumour recurrence after resection done elsewhere. In three children with inoperable disease (unresectable tumour and pulmonary and bone metastases) only palliative chemotherapy was administered.
Results: There were 9 deaths among children treated with liver resection  (28.1%), and 4 deaths in the group treated with liver transplantation (44.4%), but only 1 in 7 patients with local recurrence would was excluded (14.3%). Overall survival rate among all 44 children with HBL was 64%. Follow-up of living patients who underwent resection ranges from 1 to 190 months (mean 80
months). All deaths were due to recurrence of the disease. Follow-up of living patients who were transplanted ranges from 22 to 78 months (mean 42 months). The cause of death in OLTx group was recurrence of the disease (in metastatic form) in 3 patients and PTLD in 1 patient. All 3 children who were not qualified for surgical treatment died of hepatoblastoma.
Conclusions: With the improved selection for the two types of surgical treatment: partial liver resection or total hepatectomy and liver transplantation excellent results can be obtained in children with hepatoblastoma limited to the liver (including pts with cleared pulmonary metastases). Prognosis for the patients with recurrent disease or with inoperable tumour remains poor despite improved chemotherapy.

Keywords: Liver Transplantation

Add Comment 0 Comments

In Press

Original article  

Engraftment Syndrome in Autologous Hematopoietic Stem Cell Transplant Patients: Incidence, Associated Risk ...

Ann Transplant In Press; DOI: 10.12659/AOT.944043  

Original article  

Comparative Study of Acute Kidney Injury in Liver Transplantation: Donation after Circulatory Death versus ...

Ann Transplant In Press; DOI: 10.12659/AOT.944077  

Original article  

Abnormal Liver Biopsies of Donor Grafts in Pediatric Liver Transplantation: How Do They Fare?

Ann Transplant In Press; DOI: 10.12659/AOT.944245  

Original article  

Kidney After Lung Transplants or Combined Kidney–Lung Transplantation: A Single-Center Retrospective Cohort...

Ann Transplant In Press; DOI: 10.12659/AOT.944049  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,437

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

22 Nov 2022 : Original article   9,304

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

12 Jan 2022 : Original article   8,879

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

15 Mar 2022 : Case report   6,680

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358