Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Concentration of anti-7-ketocholesterol antibodies in serum from patients after heart transplantation

T Wielkoszyński, M Szewczyk, M Zembala

Ann Transplant 2009; 14(1): 31-31 :: ID: 880310

Abstract

Oxidized LDL have been shown to be strongly atherogenic and immunogenic in experimental animals and in humans. Similarly, autoantibodies against ox-LDL and various epitopes of ox-LDL have been detected in sera and atherosclerotic lesions. Those autoantibodies are mainly directed against adducts of lipid peroxidation products (mainly highly reactive carbonyls) and apolipoproteins or aminolipids. Oxidation of LDL may also lead to generation of oxidized derivatives of cholesterol (i.e. 7-ketocholesterol - 7-ketoCh), which are characterized by high cytotoxicity, muta- and carcinogenicity as well as
immunosuppressive effect and probably immunogenic properties. The aim of this study was quantification of autoantibodies to 7-ketoCh in sera from  patients post OHT. Antibodies in IgG class were measured in sera from 81 patients post OHT and 73 healthy volunteers with the use of home-made ELISA method. As antigen we used 7-ketoCh hemisuccinate conjugated to bovine serum albumin. Anti-7-ketoCh antibodies were detected in all examined sera. Their concentration was significantly higher in OHT patients than in control groups (respectively 109.0±109.7 and 53.5±20.0 U/ml, p<0.005).  Also relationship between antibodies concentration and time between OHT and sampling was observed. The obtained results show that also low molecular products of LDL oxidation - 7-ketoCh are immunogenic and probably anti-7-ketoCh autoantibodies can play a role in progression of atherosclerosis in OHT patients.

Keywords: Heart Transplantation

Add Comment 0 Comments

In Press

Original article  

Implementation and Evaluation of Discharge Planning for Patients Undergoing Umbilical Cord Blood Transplant...

Ann Transplant In Press; DOI: 10.12659/AOT.943770  

Original article  

Long-Term Graft and Patient Survival After Re-Transplantation

Ann Transplant In Press; DOI: 10.12659/AOT.943903  

Original article  

Post-Donation Regret and Anxiety Among Family Living Liver Donors: The Mediating Roles of Family Relationsh...

Ann Transplant In Press; DOI: 10.12659/AOT.944176  

Original article  

Effect of the Organ Donation Quality System on Donation Activity of Warsaw Hospitals

Ann Transplant In Press; DOI: 10.12659/AOT.943520  

Most Viewed Current Articles

05 Apr 2022 : Original article   12,116

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article   8,586

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article   8,504

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report   6,426

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358