Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Risk stratification of patients with severe heart failure awaiting heart transplantation – prospective national registry POLKARD HF

T Zieliński, A Browarek, M Zembala, J Sadowski, M Zakliczyński, P Przybyłowski, K Roguski, A Barańska-Kosakowska, J Korewicki, I POLKARD_HF

Ann Transplant 2009; 14(1): 31-31 :: ID: 880311

Abstract

Background: Most methods used in the risk assessment of heart transplant
candidates do not include new biomarkers. Aim: The aim of the study was to examine the value of NTproBNP and hsCRP and their combined use together with HFSS score in the risk assessment of patients with heart failure enlisted for heart transplantation.
Material/Methods: Data of 658 patients enlisted for heart transplantation were stored in a prospective registry. The primary (death or urgent transplantation) and the secondary end points (death before OHT) were recorded during the follow-up.
Results: The primary end point was recorded in 161 (24%) of pts; secondary in 102 (15%). The differences were highly significant: in Kaplan Meier curves stratified by the quartiles of NT proBNP for death or urgent transplantation (p<0.000001) and death (p<0.0002) or quartiles according to the hsCRP level on admission, (p<0.002) and (p<0.02). In the multivariate Cox proportional hazard model for death or urgent OHT, the significance was observed in NTproBNP (p<0.01) and HFSS (p<0.02), and borderline significance for hsCRP (p=0.057) for death before OHT, HFSS score P<0.00005, NTproBNP P<0.0005 and hsCRP P<0.01. A modest but significant increase of ROC value was recorded when HFSS score, NTproBNP and hs CRP were included in the model. For death or urgent OHT it was 0.638 and for death before transplantation 0.6943.
Conclusions: HFSS, NTproBNP and hsCRP levels are independent stratification variables of survival or need for urgent heart transplantation and survival before transplantation. Their predictive value is moderately increased when they are analyzed together.

Keywords: Heart Transplantation

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358