Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Neutrophils degranulation marker – leucocyte elastase-α1-protease inhibitor complex: comparative study with classic (α1M, ß2M) and novel (Ngal, Il-18) kidney graft injury markers

M Zynek-Litwin, J Kuzniar, Z Marchewka, W Kopec, W Kusztal, B Szymanska, D Patrzalek, P Biecek, M Klinger

Ann Transplant 2009; 14(1): 34-34 :: ID: 880321

Abstract

Background: Serum and urine α1M, ß2M as well as NGAL and IL-18 are
established markers of kidney graft function. The study's aim was to seek correlations between neutrophils activation (LEα[sub]1[/sub]-PI complex) and classic as  well as novel kidney graft tubulo-interstitial injury markers measured in blood and urine of deceased renal allograft's recipients.
Material/Methods: The study was performed on 24 kidney graft recipients. Using ELISA test plasma and urine LE-α[sub]1[/sub]-PI was assessed after kidney transplantation (KTx) - on postoperative (PO) days 1[sup]st[/sup], 3[sup]rd[/sup] and 7[sup]th[/sup]. Serum and urine NGAL, IL-18 and b2M were measured by ELISA test and α[sub]1[/sub]M - by  nephelometric method on 1[sup]st[/sup], 3[sup]rd[/sup], and 7[sup]th[/sup] PO day.
Results: Correlation was found between plasma LE-α[sub]1[/sub]-PI and serum NGAL on 1[sup]st[/sup] and 3rd PO day (p<0.02 and p<0.002 respectively). Urine LE-α[sub]1[/sub]-PI on 1[sup]st[/sup] PO day correlated with serum and urine NGAL on 3[sup]rd[/sup] and 7[sup]th[/sup] PO day (p<0.03; p<0.001; p<0.009 and p<0.001 respectively).There was no important
association between LE-α[sub]1[/sub]-PI and IL-18 level in serum and urine.Plasma LE-α[sub]1[/sub]-PI on the 1[sup]st[/sup] PO day was correlated with serum α[sub]1[/sub]M on 3[sup]rd[/sup], 7[sup]th[/sup] PO day Urine LE-α[sub]1[/sub]-PI on 1[sup]st[/sup] PO day correlated with serum α[sub]1[/sub]M on 1[sup]st[/sup], 3[sup]rd[/sup] and 7[sup]th[/sup] PO day and with urine α[sub]1[/sub]M on 7[sup]th[/sup] PO day as well. Similar associations were found between LE-α[sub]1[/sub]-PI on 1[sup]st[/sup] PO day and ß2M.
Conclusions: Neutrophils degranulation measured by plasma and urine LE-α[sub]1[/sub]-PI complex level was correlated with kidney graft tubulo-interstitial  damage
markers in the early period after KTx.

Keywords: Ischemia reperfusion injury, Kidney Transplantation

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358