Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

The relationship between coronary artery calcification and pulse wave velocity in renal transplant recipients

A Adamowicz, P Stróżecki, Z Serafin, Z Włodarczyk, J Manitius, W Lasek

Ann Transplant 2009; 14(1): 34-34 :: ID: 880322

Abstract

Background: Coronary artery calcification (CAC) and increased PWV are responsible for high incidence of ischemic heart disease and other cardiovascular complications in patients with chronic kidney disease (CKD). Pulse wave velocity (PWV) is a marker of arterial stiffness and independent cardiovascular risk factor in renal transplant recipients (RTR). Relationship between CAC and PWV was found in CKD patients and in non-renal population. The aim of the study was to evaluate the relationship between CAC and PWV in RTR.
Material/Methods: The study group consisted of 104 RTR (31 females and 73
males), aged 49±12 years. All patients received graft from the deceased donors. Total duration of renal replacement therapy (RRT) was 71±47 months.
PWV between carotid and femoral artery was measured using Complior device. CAC was determined with multi-detector row computed tomography as a total calcium score (CS) and calcium mass (CM). Systolic and diastolic blood pressure (SBP, DBP) were measured, then pulse pressure (PP) was calculated. Glomerular filtration rate was calculated with abbreviated MDRD
equation (eGFR). Results are expressed as mean ±SD.
Results: CAC was found in 72 patients (69%). We compared RTR without CAC and those with CAC. We found significant positive correlation between PWV
and: CS (r=0.21; p<0.05), and CM (r=0.20; p<0.05). In multiple logistic regression analysis PWV was independent predictor of CAC - OR 1.82 (95% confidence interval: 1.18-2.31, p<0.01).
Conclusions: The study revealed high prevalence of CAC in RTR. PWV is an independent predictor of coronary artery calcification in RTR. Further studies are necessary to identify other than age and male gender pathogenic factors for both: CAC and increased arterial stiffness.

Keywords: Kidney Transplantation

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358