Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Cytometric analysis of CD4+CD25+FOXP3+ regulatory t cells in peripheral blood of patients undergoing kideny transplantation

M Karczewski, J Karczewski, M Głyda, K Wiktorowicz

Ann Transplant 2009; 14(1): 37-37 :: ID: 880333


Background: CD4 CD25 Foxp3 regulatory T cells (Tregs) represent 5-10% of peripheral CD4 T cells and have been suggested to prevent acute graft rejection (AR). Our project was aimed to investigate the relation between the level of pre-transplant and post-transplant peripheral Tregs and the development of AR episodes in patients after kidney transplantation.
Material/Methods: The project included 44 patients undergoing kidney
transplantation. During the six-months period following the transplantation AR
was diagnosed in 11 patients. Peripheral blood samples were collected 1 day before and 10 days after the transplantation and cytometrically tested for concentrations of Tregs.
Results: The pre-transplant analysis showed significantly lower levels of peripheral Tregs in AR patients vs. control. A lower level of Tregs was also observed in NONAR patients vs. control, however, it was still higher than in the AR group. The 10-day post-transplantation analysis showed a similar pattern,
however, a significant increase in the concentration of Tregs in NONAR patients was observed, whereas no change was recorded in AR patients.
Conclusions: Lower pre-transplant levels of peripheral Tregs were found in both groups, AR and NONAR vs. control group. The deficiency of Tregs in patients with end-stage renal failure might be due to the long-term inflammatory processes adversely affecting the peripheral regulatory mechanisms, however significantly lower levels of Tregs observed in AR patients might also be related to genetic predispositions. Our observation suggests that the size and possibly the functionality of Tregs in AR group was not sufficient to successfully control the immune response after kidney transplantation leading to AR.

Keywords: Immunosuppression, Kidney Transplantation, Tissue typing

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358