21 May 2009
Histopathological assessment of explanted liver in patients transplanted for undetermined origin of acute and chronic liver failure
K Dudek, B Ziarkiewicz-Wróblewska, M Sielska, R Gryszkiewicz, K Kobryń, P Remiszewski, T Wróblewski, K Zieniewicz, M KrawczykAnn Transplant 2009; 14(1): 42-42 :: ID: 880350
Abstract
Background: The diagnosis of an underlying liver disease should be made
before a patient is listed for transplantation, but in a significant number of
patients we overlooked a concurrent disease and patient was qualified on the waiting list with the diagnosis of idiopathic liver failure. Aim: To assess the aetiology and outcome of patients with indeterminate origin of chronic and acute liver failure in the authors' institution.
MaterialMethods: From 2001 to 2008, 655 OLTx were performed. In the group of 47 patients, a median age of 43.4±18.2 years - 7% of total group of patients - aetiology of liver failure was unclear before the liver transplantation. Clinicopathological factors, including treatment variables, outcome of liver transplantation and establishment of the final diagnosis of the explanted liver specimen were analyzed.
Results: Our study shows that histopathology expertise can help to clarify the
diagnosis in only about 34% of cases. In analyzed specimens occurred most
frequently: toxic and alcoholic cirrhosis in 7 patients, Wilson's disease in 4
patients, autoimmune hepatitis in 3 patients, acute Budd-Chiari syndrome and viral hepatitis - each in 1 case.
Conclusions: Precise identification of post-transplant specimen is to a great
extent possible, if the pathologist is adequately provided with all essential
clinical and anamnesis' data. Despite of advance in histopathological and
inmmunohistopathological examinations in 4% of patients', aetiology of liver failure still remained unclear.
Keywords: Liver Transplantation
In Press
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
18 Mar 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of R...Ann Transplant In Press; DOI: 10.12659/AOT.943282
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860