21 May 2009
Anemia prevalence and a possible role of hepcidin in its pathogenesis in kidney allograft recipients
J Malyszko, J Malyszko, M MysliwiecAnn Transplant 2009; 14(1): 48-49 :: ID: 880376
Abstract
Hepcidin is a small defensin-like peptide whose production by hepatocytes is modulated in response to anaemia, hypoxia or infl ammation. We studied hepcidin correlations with markers of iron status, erythropoietin therapy and markers of inflammation in 100 prevalent kidney allograft recipients-Tx. In addition, prevalence of anaemia and its relation to hepcidin was also assessed. Soluble receptor of transferrin-sTfR hsCRP, TNF alpha, IL-6, prohepcidin and hepcidin were measured using commercially available kits.According to WHO definition, prevalence of anaemia was 28%. In anaemic Tx we found a significantly higher serum creatinine, serum prohepcidin, hepcidin, CRP, TNF alpha, IL-6, ferritin, proteinuria, higher use of rapamycin (n=8), and significantly lower use of CSA, lower CSA concentration, lower cholesterol, lower haemoglobin, lower eGFR (MDRD). Serum prohepcidin correlated significantly with creatinine, GFR, time after transplantation, albumin, hsCRP, IL-6 and TNF alpha, whereas hepcidin-25 correlated with serum iron, ferritin, CRP, IL-6, haemoglobin, TSAT, creatinine, GFR. Multiple regression analysis showed that prohepcidin was independently related only to GFR and ferritin. In multiple regressions analysispredictors of serum hepcidin were eGFR, TSAT and hsCRP explaining 79% of the variation of hepcidin.
Conclusions: Prevalence of anaemia is relatively high in population of kidney allograft recipients and not adequately treated (mainly due to reimbursement regulations). Elevated hepcidin levels in kidney transplant recipients may be due to low grade inflammation, frequently encountered in this population and mainly to impaired renal function, but it does not seem to be a major pathogenetic factor of anaemia in this population.
Keywords: Kidney Transplantation
In Press
04 Aug 2022 : Original article
Long-Term Patency of All-in-One Sleeve Patch Graft Venoplasty in 16 Patients Who Underwent Living Donor Liv...Ann Transplant In Press; DOI: 10.12659/AOT.936888
22 Jul 2022 : Original article
Diagnostic Role of Tumor Markers for Hepatocellular Carcinoma in Liver Transplantation Candidates: An Analy...Ann Transplant In Press; DOI: 10.12659/AOT.936937
22 Jul 2022 : Original article
Development of a Novel Model for Predicting Postoperative Short-Term Outcome in Patients with Hepatitis B-R...Ann Transplant In Press; DOI: 10.12659/AOT.936732
22 Jul 2022 : Original article
Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant RecipientsAnn Transplant In Press; DOI: 10.12659/AOT.936751
Most Viewed Current Articles
26 Jan 2022 : Review article
Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive ModelsDOI :10.12659/AOT.934924
Ann Transplant 2022; 27:e934924
29 Dec 2021 : Original article
Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...DOI :10.12659/AOT.933588
Ann Transplant 2021; 26:e933588
24 Jul 2020 : Review article
Kidney Transplantation in the Times of COVID-19 – A Literature ReviewDOI :10.12659/AOT.925755
Ann Transplant 2020; 25:e925755
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860