Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Pregnancy after kidney transplantation – a single centre experience

J Gałgowska, A Dębska-Ślizień, W Wołyniec, A Milecka, G Moszkowska, B Rutkowski

Ann Transplant 2009; 14(1): 49-49 :: ID: 880379

Abstract

Background: Successful pregnancy in haemodialysed women is rare. After
kidney transplantation (KT) pregnancy is possible but the risk of maternal
and foetal complications is increased.
Material/Methods: We examined retrospectively the outcome of 15 pregnancies in 13 patients after KT in Gdańsk centre in the period 1987-2008.
Results: Mean maternal age at pregnancy was 29.7±4.2 (range 24-37) years.
Mean interval between transplantation and conception was 30.9±18.6 (range
7-62) months. Mean creatinine concentration at conception was 1.35±0.39
(range 0.9-2.45) mg/dl, hypertension was presented in 7/13 women (2 received more than 1 anti- hypertensive drug), none had urine spot proteinuria. There were 2 conceptions within the first year of transplantation, and 6 within the second year of transplantation. Out of 13 women, 8 were primagravidas. At conception, 8 women received protocol with cyclosporine (CsA/MMF/P - 4, CsA/Aza/P - 4), 3 with tacrolimus (TAC/MMF/P-2, TAC/Rapa-1), and 2 azathioprine with prednisone. Mycofenolate mofetil was discontinued before pregnancy and rapamycine during the first few weeks of pregnancy. Foetal outcomes included: 13 live births, 1 spontaneous abortion, and 1 stillbirth. Mean pregnancy age was 35.5±3.5 (range 26-39) weeks. There were 9 caesarean sections. Among the live births, there was 1 neonatal death due to multiple lethal malformations, 1 child developed a severe neurological defect. There was 1 case of imminent asphyxia. Out of 15 pregnancies, maternal complications included ankle oedema (4/13), worsening of blood pressure control (3/13), 1 imminent abortion, 1 cervical insufficiency, 1 anhydramion. One mother returned on dialysis 7 years after successful pregnancy, the remaining live with functioning grafts.

Keywords: Kidney Transplantation

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358