Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Conversion from cyclosporine microemulsion (CyA-Me) to tacrolimus (TAC) in kidney allograft recipients

A Chamienia, B Biedunkiewicz, A Dębska-Ślizień, B Rutkowski

Ann Transplant 2009; 14(1): 56-56 :: ID: 880404


Background: Available data suggests that cyclosporin and tacrolimus differ in respect of nephrotoxicity and long term graft function in kidney transplantation. The aim of this study was to evaluate the impact of converting stable kidney allograft recipients from CyA-Me to TAC on renal function and cardiovascular risk profile.
Material/Methods: 31 patients with stable renal function (Scr <3.0 mg/dl) were successfully switched from CyA-Me to TAC and followed up for 24 months. Majority (77.4%) had suspicion of CyA nephrotoxicity. Renal function was measured as serum creatinine (Scr) and calculated GFR. Office blood pressure and lipid profiles were evaluated.
Results: 29 patients fi nished the 24 month observation period. 1 and 2 year patient's survival was 100%; graft's survival was 93.5% and 91% respectively. No new cases of diabetes mellitus were identified. Mean SCr fell from 2.28±0.4 to 1.95±0.4 mg/dl (P<.02) and calculated GFR increased from 49.1±15 to 55.2±16 mL/min (P<.05). Total cholesterol decreased from 236±50 to 190±31 mg/dL (P <.02), LDL cholesterol from 132±36 to 105±23 mg/dL (P<.02). No significant changes in mean systolic or diastolic pressure were observed although numerically both systolic and diastolic BP had tendency to fall. Blood glucose levels were unchanged.
Conclusions: Our results show that this group of patients with increased creatinine at entry conversion to TAC resulted in improved graft function and more favourable cardiovascular risk profile, which may result in longer graft halflife, but the observation period was too short to confi rm such statement.

Keywords: Kidney Transplantation

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358