Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Dyslipidaemia in lung transplant recipients during short and long term follow UP

S Zeglen, J Wojarski, E Wozniak-Grygiel, R Buldak, E Kucewicz, M Zembala

Ann Transplant 2009; 14(1): 61-61 :: ID: 880421


Background: Hypercholesterolemia is a frequent complication in lung transplant recipients but the mechanisms contributing to its development are not exactly known.
Material/Methods: Total cholesterol levels (Chol, [mmol/L]) as well as lipoproteins like HDL (mmol/L), LDL (mmol/L) and TG, (mmol/L) were  retrospectively analysed in 15 lung transplant recipients (2 women and 13 men, mean age 46.2±12.1, BMI 20.5±4.2) in various post-transplantation periods (early-eTP up to 30 days and long-lTP up to two years after LTx). Lipoproteins were estimated using routine enzyme/colorimetric method (Cobas-Integra).
Results: In eTP period mean cholesterol value was 4.57±0.37 (in 23% of patients values were above normal); HDL was 1.03±0.19 (in 30.8% values were decreased); mean LDL value was 2.8±0.36 (30.8% values above the normal); TG 2.26±0.66 were upregulated (in 61.5% patients upper than normal). Mean cholesterol in late period (lTP) was 4.01±0.53 (in 16.7% patients above normal); HDL 1.25±0.23 (in 8.3% of subjects values were down-regulated); LDL was 2.49±0.54 (16.7% of patients presented increased values); TG were 1.55±0.43 (33.3% of patients had upper values than normal). There were no differences in lipid disturbances between studied periods. There was no difference in lipids between tacrolimus and cyclosporine groups with an exception of total cholesterol (4.09±0.4 vs. 4.92±0.97 p<0.05; HDL 1.14±0.26 vs. 1.23±0.21 p>0.05; LDL 2.36±0.45 vs. 3.07±0.73 p>0.05; TG 1.48±0.47 vs. 2.25±0.57).
Conclusions: Clinically significant percentage of patients presented atherogenic constellation of lipoproteins -high TG, LDL and low HDL. It could also be
concluded that tacrolimus might be less atherogenic than cyclosporine.

Keywords: Lung Transplantation

Add Comment 0 Comments

In Press

06 Feb 2024 : Case report  

Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal ...

Ann Transplant In Press; DOI: 10.12659/AOT.941881  

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358