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21 May 2009

Cellular rejection itself is accompanied with slight kidney and liver dysfunction in heart transplant recipients

S Zeglen, E Wozniak-Grygiel, M Zakliczynski, R Buldak, E Herczakowska, H Czarnecka, M Zembala

Ann Transplant 2009; 14(1): 62-62 :: ID: 880425

Abstract

Background: The renal and liver dysfunction is a frequent complication after heart transplantation (HTx). We tried to analyse the impact of rejection episode on its function. Therefore, bilirubin (Bil; umol/L), aspartate (AspAt; IU/L) and alanine (AlAt; IU/L) amionotransferases, alkaline phosphatase (ALP; IU/L), gamma-glutamyl transferase (GGT; IU/L) as well as creatinine (Cr; umol/L), creatinine-based GFR (mL/min/1.73 m[sup]2)[/sup] were estimated during rejection grade 3a/3b (due to ISHLT scale) just before and after rejection treatment (group II and III, respectively) comparing to period when biopsies were 0 (group I). Parameters were analysed also in the context of immunosuppression (cyclosporin- CsA vs. tacrolimus-Tac).
Material/Methods: 32 patients were included into the trial (6 women and 26 men, mean age 51.6±3.9 yr, BMI 24.7±2.5). Endomyocardial biopsy specimens were processed using routine method. Serum values of all liver enzymes, Bil and Cr were measured using a Cobas Integra 400/800 (Roche, USA). GFR was estimated by Cr predicted clearance based on MDRD.
Results: The increase of GGT in group II was noted when compared to group I and III (139.0±70 vs. 25.5±29 and 97.0±62, p<0.05; respectively). The decrease of GFR value was observed in group I in compare to group III (68.4±19.8 vs. 8

Keywords: Heart Transplantation

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358