21 May 2009
Myocardial fibrosis and cardiocyte diameter are the most important factors discriminating histostructure of dilatative and ischemic cardiomyopathy – study of hearts explanted from transplant recipient
J Nożyński, M Zakliczyński, D Konecka-Mrówka, E Zembala-Nożyńska, D Lange, K Dąbrówka, T Męcik-Kronenberg, S Żegleń, R Przybylski, M ZembalaAnn Transplant 2009; 14(1): 64-65 :: ID: 880435
Abstract
Background: Interstitial fibrosis and variations in cardiocyte hypertrophy belong to the remodelling activities taking place in diseased myocardium especially in dilatative cardiomyopathy (DCM) and ischemic heart disease (IHD). The integrative morphometric measurements should reflect the main differences in histoarchitecture giving a valuable diagnostic tool. We sought to evaluate the quantitative morphology of the explanted diseased heart with DCM and IHD.
Material/Methods: The study groups encompassed 7 hearts with DCM and 8
hearts with IHD explanted during transplantation. The comparative group consisted of myocardial hypertrophy, while the control group were donor fragments. Method. Myocardial histoarchitecture was evaluated morphometrically in histological slides. The cardiocyte hypertrophy was estimated as nucleo-sarcoplasmic ratio calculated from nuclear and cardiocytic integrative measurements; cardiocyte diameter was additionally measured as mean chord, and myocardial interstitial fibrosis - as fibrosis surface area fraction in trichrome stained slides. The results were compared statistically and analyzed with discriminate analysis.
Results: The cardiocyte diameter showed no statistical significance between
myocardial hypertrophy and IHD and IHD and DCM, whereas nucleo-sarcoplasmic ratio showed differences in all comparisons with control groups. Myocardial fibrosis showed no differences between hypertrophy and control. Discriminate analysis pointed out the value of interstitial fibrosis and cardiocytes diameter in differentiating of analyzed groups, then proximity between control and hypertrophy and IHD and DCM and hypertrophy.
Conclusions: Myocardial fibrosis and cardiocytes' diameter may play a role as key parameters for diagnosis and differentiation of cardiomyopathies.
Keywords: Heart Transplantation
In Press
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
18 Mar 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of R...Ann Transplant In Press; DOI: 10.12659/AOT.943282
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860