Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Anaemia and its predictors in heart transplant recipients

P Przybyłowski, J Małyszko, J Małyszko

Ann Transplant 2009; 14(1): 66-66 :: ID: 880441

Abstract

Cardiovascular disease and kidney disease are like Siamese twins sharing
similar characteristics. It has been recently recognized that many patients with cardiovascular disease are anaemic. The anaemia is very often associated with kidney dysfunction. Even, the term cardio-renal anaemia syndrome was endorsed to stress the dangerous associations. The aim of the study was to assess prevalence of anaemia in relation to chronic kidney disease in 162
consecutive patients after heart transplantation. According to WHO's definition (haemoglobin less than 13 g/dl for males and less than 12 g/dl for females) prevalence of anaemia in the studied cohort was 41%. Anaemic patients had significantly lower GFR (MDRD and Cockcroft-Gault 44.46±26.84 ml/min vs. 62.70±24.15 ml/min, and 48.93±27.80 ml/min vs. 72.11±29.76 ml/min, p<0.001 respectively), creatinine clearance, lower RBC, haemoglobin, ejection fraction and significantly higher creatinine, NT-proBNP. Presence of anaemia was related to the time after transplantation, GFR, creatinine clearance, creatinine, NT-proBNP, cholesterol, ejection fraction. In multiple regression analysis the only predictor of anaemia was the kidney function (GFR or creatinine clearance) explaining 22% of the variation. Type of immunosuppressive regimen (CNI vs. mTOR inhibitors vs. MMF) did not affect prevalence of anaemia in this studied population. Prevalence of anaemia is relatively high in population of heart allograft recipients and not adequately treated (mainly due to reimbursement regulations). In patients with cardiovascular disease, GFR should be estimated since renal dysfunction and subsequent anaemia are the ones of more important risk for cardiovascular morbidity and mortality. It should be noted also that chronic heart failure is also more common in anaemic patients.

Keywords: Heart Transplantation

Add Comment 0 Comments

In Press

Original article  

Retrospective Study to Compare Outcomes in 159 Patients Undergoing First Autologous Stem Cell Transplantati...

Ann Transplant In Press; DOI: 10.12659/AOT.947186  

Case report  

Pulmonary Embolism Following Living Donor Hepatectomy: A Report of 4 Cases and Literature Review

Ann Transplant In Press; DOI: 10.12659/AOT.946752  

Most Viewed Current Articles

03 Jan 2023 : Original article   6,492

Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...

DOI :10.12659/AOT.938467

Ann Transplant 2023; 28:e938467

16 May 2023 : Original article   6,128

Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...

DOI :10.12659/AOT.939258

Ann Transplant 2023; 28:e939258

15 Aug 2023 : Review article   6,133

Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ Transplantation

DOI :10.12659/AOT.939750

Ann Transplant 2023; 28:e939750

17 Jan 2023 : Original article   5,256

Non-Cryopreserved Peripheral Blood Stem Cell Graft for Autologous Hematopoietic Stem Cell Transplantation i...

DOI :10.12659/AOT.938595

Ann Transplant 2023; 28:e938595

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358