21 May 2009
Tissue banking on the move – from non-vital grafts to cell cultures. A review of the current status and prospects in chondrocytes culture techniques for autologous chondrocytes implantation
E Olender, A Kamiński, I Uhrynowska-TyszkiewiczAnn Transplant 2009; 14(1): 68-68 :: ID: 880450
Abstract
Background: Historically, tissue banks' activities have focused mainly on retrieving and processing tissues, i.e. more or less organized conglomerates of cells and intracellular matrix. Unlike organ grafts, many kinds of tissue grafts do not have to even contain living cells to perform their task properly. And so, the cells as such, have been paid less attention. This situation changes with the shift towards the new cell-based therapies. A recent example of this trend is introducing autologous chondrocytes culture into tissue banks' procedures. The aim of this paper is to review the status of the chondrocytes culturing for autologous implantation and its implications for tissue banks' activities. Design: Basing on a systematic literature review the following topics will be discussed: characteristics of chondrocytes as a specific kind of cells, principles of chondrocytes culture, limitations imposed by the physiology of chondrocytes, attempts to optimize culture and implantation conditions, methods for assessing the state of chondrocyte differentiation, the possible alternative sources of cells for cartilage repair. Issues concerning the specific legal status of cell culturing will also be raised.
Conclusions: The traditional perception of the tissue banks just as facilities
processing and storing non-vital tissue grafts does not correspond with the
current state. Tissue banks are involved not only in simple propagation of
cells but also in designing new culture techniques and cell carriers in order
to deliver cells of desired characteristics. This presents technological challenges in terms of scientific progress and adjusting tissue banks' activities to meet international standards.
Keywords: biostatic grafts, Tissue Banking, Tissue Transplantation
In Press
Original article
The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival Afte...Ann Transplant In Press; DOI: 10.12659/AOT.945249
Original article
Biopsychosocial Effects of Donor Traits on Heart Transplant RecipientsAnn Transplant In Press; DOI:
Clinical Research
Ten-Year Retrospective Analysis of Continuous Renal Replacement Therapy in Burn Patients: Impact on Surviva...Ann Transplant In Press; DOI:
Original article
Factors Influencing Stress Disorders in Intensive Care Unit (ICU) Patients After Liver Transplantation: A C...Ann Transplant In Press; DOI: 10.12659/AOT.944320
Most Viewed Current Articles
05 Apr 2022 : Original article 13,113
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
22 Nov 2022 : Original article 10,260
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
12 Jan 2022 : Original article 9,611
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
15 Mar 2022 : Case report 7,271
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860