Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

21 May 2009

Procalcitonin upregulation is associated with pneumocystis jiroveci colonization as well as pseudomonas aeruginosa infection/colonisation in lung transplant recipients

S Zeglen, M Siola, E Wozniak-Grygiel, J Wojarski, M Szewczyk, M Zembala

Ann Transplant 2009; 14(1): 72-73 :: ID: 880466


Background: Allograft infection after lung transplantation has a significant impact on the procedure outcome and could be a diagnostic challenge. Pneumocystis jirovecii is an opportunistic infection causing life-threatening pneumonia (PCP) in immunocompromised patients. Airway colonisation with Pseudomonas aeruginosa is common in lung transplant (LTx) recipients. The aim of the study was to compare a retrospective case review of Pneumocystis jiroveci and Pseudomonas aeruginosa infections in lung transplant's (LTx) recipients and compare them with serum procalcitonin concentrations (PCT).
Material/Methods: 15 LTx patients were retrospectively involved into the study (10 men and 5 women, mean age: 41.4±14.6 yr.). In 7 patients cysts of P. jiroveci were diagnosed (group J) and in 13 patients P. aeruginosa (group A) was isolated. In respiratory samples P. jiroveci was detected using indirectimmunofluorescence method and P. aeruginosa was isolated using routine microbiological methods. PCT was measured using immunoluminescence assay (ILMA; BRAHMS PCT LIA, Berlin, Germany).
Results: Average PCT value in group A was 0.30±0.21 and in group J was 0.88±0.43, the difference was not significant. In group A 3 patients (23.1%) had PCT value indicating moderate infection risk (PCT >0.5) and 1 patient (7.7%) high infection risk (PCT >2.0 and <10). In group J 3 patients (42.9%) had PCT value indicating moderate and 1 patient (14.3%) high infection risk.
Conclusions: Bronchial tree colonization with Pneumocystis jiroveci as well as
Pseudomonas aeruginosa infection/colonization are associated with moderate
procalcitonin increase suggesting general systemic response, also during colonization of only bronchi of the transplanted lung.

Keywords: Lung Transplantation

Add Comment 0 Comments

In Press

06 Feb 2024 : Case report  

Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal ...

Ann Transplant In Press; DOI: 10.12659/AOT.941881  

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358