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21 May 2009

Influence of viral infections on allografts function and acute graft rejection (agr) in both donors and recipients

P Jurkowski, A Mikłaszewicz, M Cićkiewicz, P Orszulak, M Fiedor, Z Lewandowski, P Fiedor

Ann Transplant 2009; 14(1): 74-74 :: ID: 880471

Abstract

Background: Virus infections play a key role and directly influence allograft
function in recipients under chronic immunosuppression. The aim of this study was to evaluate the infl uence of CMV, EBV, HBV and HCV virus infections in both donors and recipients on graft stability.
Material/Methods: The medical histories of 171 kidney and liver allograft recipients were analyzed in search of viral infections. Next, every recipient was matched with their donors. It was evaluated how different viral infections influence the time of acute graft rejection.
Results: There was no significant difference in the time of acute rejection time between HBVAg positive and HBVAg negative recipients (p>0.05). Seven months after transplantation, the number of Anti-HCV positive recipients after AGR was twice as big as the number of Anti-HCV negative patients (p=0.0176). Seven months after transplantation, the number of CMV-IgM positive recipients after AGR was three times as big as the number of CMV-IgM negative patients(p=0.0292). There was found no correlation between EBV infection and acute rejection time.
Conclusions: Our data strongly indicate that both HCV and CMV virus infections worsen allograft stability in transplant recipients and immunosuppression is an independent risk factor.

Keywords: CMV infections, HBV infection, HCV infection, viral infections

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358