21 May 2009
Analysis of risk factors influencing acute graft rejection in allograft recipients
P Jurkowski, A Mikłaszewicz, M Cićkiewicz, P Orszulak, M Fiedor, Z Lewandowski, P FiedorAnn Transplant 2009; 14(1): 76-76 :: ID: 880480
Abstract
Background: Stability of graft function after allotransplantation is difficult to maintain. There are many factors that can worsen recipient's condition and may lead to acute graft rejection. The aim of this study was to evaluate the influence of various factors on the incidence of acute graft rejection episodes in patients after liver and kidney allotransplantation.
Material/Methods: 171 recipients after kidney and liver transplantation were
analyzed. Factors of interest included: immunosuppression patterns, existence of diabetes, received induction therapy, warm and cold ischemia time and acute rejection time. Next, the data of donors for the 171 patients was collected. All data was statistically analyzed.
Results: The number of kidney and liver recipients without acute graft rejection was the lowest for CsA and CellCept model compared to the highest for CsA and Aza model (p=0.0008). Tacrolimus causes the highest risk of induced diabetes after transplantation (p<0.001). The number of kidney and liver recipients with acute graft rejection was higher in patients who received graft from females comparing with the group who received grafts from males (p=0.0282). Every minute of warm ischemia time increases the risk of acute
graft rejection by 12.7%. The percentage of patients without AGR after 7 months with 2 common alleles, 1 common allele and 0 common alleles in HLA-DR was 100%, 55% and 30% respectively (p=0.0128).
Conclusions: The acute rejection time depends on many factors and how they affect graft stability was elucidated in this study.
Keywords: Immunosuppression, Kidney Transplantation, Liver Transplantation
In Press
15 Mar 2024 : Review article
Approaches and Challenges in the Current Management of Cytomegalovirus in Transplant Recipients: Highlighti...Ann Transplant In Press; DOI: 10.12659/AOT.941185
18 Mar 2024 : Original article
Does Antibiotic Use Increase the Risk of Post-Transplantation Diabetes Mellitus? A Retrospective Study of R...Ann Transplant In Press; DOI: 10.12659/AOT.943282
20 Mar 2024 : Original article
Transplant Nephrectomy: A Comparative Study of Timing and Techniques in a Single InstitutionAnn Transplant In Press; DOI: 10.12659/AOT.942252
28 Mar 2024 : Original article
Association Between FEV₁ Decline Rate and Mortality in Long-Term Follow-Up of a 21-Patient Pilot Clinical T...Ann Transplant In Press; DOI: 10.12659/AOT.942823
Most Viewed Current Articles
05 Apr 2022 : Original article
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
12 Jan 2022 : Original article
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
22 Nov 2022 : Original article
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
15 Mar 2022 : Case report
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860