Abstract

Background: Platelate dysfunction is well known factor that may play a role in bleeding diathesis in uremia In recent years, Platelet Function Assay 100 (PFA-100) was introduced to measure platelet function. The purpose of this study was to determine whether an abnormal PFA-100 is an accurate predictor of bleeding in dialysis patients undergoing renal transplantation (RTx).
Material/Methods: We included 98 dialysis patients undergoing RTx operation. PFA-100 test measuring collagen/epinephrine (Col/EPI) and collagen/adenosine 5'-diphosphate (Col/ADP) closure was performed in each patients after induction of anesthesia. We compared intraoperative blood loss measured by gravimetric method during RTx operation method between patients with normal Col/EPI and Col/ADP closure times (group 1, n= 51) and with prolonged Col/EPI and Col/ADP closure times (group 2, n=47).
Results: Intraoperative blood loss calculated by gravimetric method was 273±50 ml in the group 1 and 303±109 ml in the group 2 (p>0.05). Blood loss in gross formula was 356±87 ml in the group 1 and 450±99 ml in group 2 (p>0.05).
Conclusions: Assessment of platelet function with preoperative measurement of PFA-100 in RTx patients is not an effective method for estimating the risk of blood loss in the intraoperative and postoperative periods.

Keywords: renal transplantation, PFA-100