Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

28 June 2010

Significance of Epstein-Barr virus infection in the outcome of renal transplant patients with lymphoproliferative disorders

Hossein Khedmat, Seyed Moayed Alavian, Saeed Taheri

Ann Transplant 2010; 15(2): 40-44 :: ID: 880939

Abstract

Background: The impact of EBV infection on the incidence of post-transplant lymphoproliferative disorders (PTLDs) is well established, but scant data exists on the significance of such an infection on organ transplant recipients who develop lymphoproliferative disorders. In the present study, we investigated the epidemiology of EBV infection in renal transplant recipients developing post-transplant lymphoproliferative disorders and its potential impact on these patients.
Material/Methods: International data from 5 different studies were included in the analysis. Complete remission (CR) was defined as no evidence of disease by different diagnostic methods. Partial remission was defined as a substantial decrease in measurable known lesions without the appearance of new ones.
Results: Overall 45 PTLD patients were included into analysis. Remission rate was significantly higher in EBV negative patients (p=0.010). Patients with EBV infection had significantly lower patient survival rate (p=0.06). Incidence of early onset PTLDs was significantly related to EBV infection (p=0.02).
Conclusions: This study demonstrates EBV infection is a major complication in post-transplant lymphoproliferative patients. Physicians should more intensively follow their EBV-infected transplant patients who have lymphoproliferative disorders.

Keywords: post-transplant lymphoproliferative disorders, Outcome, PTLD, Epstein Barr virus

Add Comment 0 Comments

In Press

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358