28 June 2010
Significance of Epstein-Barr virus infection in the outcome of renal transplant patients with lymphoproliferative disorders
Hossein Khedmat, Seyed Moayed Alavian, Saeed TaheriAnn Transplant 2010; 15(2): 40-44 :: ID: 880939
Abstract
Background: The impact of EBV infection on the incidence of post-transplant lymphoproliferative disorders (PTLDs) is well established, but scant data exists on the significance of such an infection on organ transplant recipients who develop lymphoproliferative disorders. In the present study, we investigated the epidemiology of EBV infection in renal transplant recipients developing post-transplant lymphoproliferative disorders and its potential impact on these patients.
Material/Methods: International data from 5 different studies were included in the analysis. Complete remission (CR) was defined as no evidence of disease by different diagnostic methods. Partial remission was defined as a substantial decrease in measurable known lesions without the appearance of new ones.
Results: Overall 45 PTLD patients were included into analysis. Remission rate was significantly higher in EBV negative patients (p=0.010). Patients with EBV infection had significantly lower patient survival rate (p=0.06). Incidence of early onset PTLDs was significantly related to EBV infection (p=0.02).
Conclusions: This study demonstrates EBV infection is a major complication in post-transplant lymphoproliferative patients. Physicians should more intensively follow their EBV-infected transplant patients who have lymphoproliferative disorders.
Keywords: post-transplant lymphoproliferative disorders, Outcome, PTLD, Epstein Barr virus
In Press
Original article
Post-Liver Transplantation Atrial Fibrillation: Insights into Clinical and ECG PredictorsAnn Transplant In Press; DOI: 10.12659/AOT.948243
Original article
Prognostic Nutritional Index Trajectories Predict Kidney Function in Kidney Transplant Recipients: A Latent...Ann Transplant In Press; DOI: 10.12659/AOT.947388
Most Viewed Current Articles
03 Jan 2023 : Original article 6,942
Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...DOI :10.12659/AOT.938467
Ann Transplant 2023; 28:e938467
15 Aug 2023 : Review article 6,909
Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ TransplantationDOI :10.12659/AOT.939750
Ann Transplant 2023; 28:e939750
16 May 2023 : Original article 6,682
Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...DOI :10.12659/AOT.939258
Ann Transplant 2023; 28:e939258
28 May 2024 : Original article 6,102
Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...DOI :10.12659/AOT.943281
Ann Transplant 2024; 29:e943281