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22 December 2010

Liver transplantation with ABO incompatible graft under immunoadsorption protocol – case report

Malgorzata Markiewicz-Kijewska, Piotr Kalicinski, Joanna Teisseyre, Hor Ismail, Anna Ostoja-Chyzynska, Sylwester Prokurat, Irena Sokolnicka

Ann Transplant 2010; 15(4): 68-71 :: ID: 881354

Abstract

Background: ABO incompatible liver transplantation is still controversial, but accepted in selected cases. Recently several authors reported use of the new technology aimed at elimination anti-donor ABO specific hemagglutinins to assist immunosuppression in preventing acute rejection after transplantation.
Case Reoprt: We report two cases of liver transplantation in children with ABO incompatible graft under immunoadsorption protocol. Both patients were transplanted urgently (one due to acute decompensation of chronic liver failure and second due to acute liver failure) with ABO incompatible liver grafts. Both patients were in very poor general condition with deterioration of neurological status and there were no suitable ABO compatible grafts at the time. In both cases immunosuppressive protocol consisted of induction with basiliximab, followed by tacrolimus, mycophenolate mofetil and corticosteroids. Additionally in both patients 3 immunoadsorption sessions with Glycosorb ABO® system (Glycorex AB, Sweden), were performed. There were no any acute rejection episodes till now. The only problem observed after transplantation was mild anemia due to low grade hemolysis in the postoperative period. Both patients are alive and well with very good liver function 20 and 26 months after transplantation.
Conclusions: Immunoadsorption therapy can be safely and effectively introduced in recipients of ABO incompatibile donor liver.

Keywords: liver transplantation across blood groups, immunoadsorption protocol, children and adolescence

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358