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22 December 2010

Nineteen years of experience utilizing anti-T-Lymphocyte globulin induction in pediatric kidney transplantation

Conceicao Mota, Lassalete Martins, Teresa Costa, Leonidio Dias, Manuela Almeida, Josefina Santos, M. Sameiro Faria, A. Castro Henriques, Rui Almeida

Ann Transplant 2010; 15(4): 84-91 :: ID: 881356

Abstract

Backgroud: The optimal immunosuppressive therapy in kidney transplantation remains controversial. Since 1990, we included, in our department, anti-T-Lymphocyte globulin Fresenius® (ATG-F) in a sequential immunossupressive therapy in pediatric recipients of deceased donor kidneys. We analysed retrospectively the complications and long-term outcomes.
Material/Methods: Ninety eight kidney transplants were performed in 91 children and adolescents between November 1990 and October 2009, using deceased donor source grafts. In 86.8% of the recipients ATG-F was used as antibody induction and in 12.2% of the recipients no ATG-F induction was used.
Results: Overall graft survival rates at 1, 5, 10 and 15 years were 91.8%, 86.1%, 75.9% and 61.9% respectively. In the ATG-F group the graft survival at 1, 5, 10 and 15 years was 93%, 89.1%, 79%, 62.4% and in group without ATG-F it was 83.3%, 66.7%, 55.6% at 1, 5, 10 years respectively (p=0.27). The overall incidence of infection was 1.6/patient in the first year post-transplantation and almost all were of mild or moderate intensity. A papillary thyroid carcinoma was diagnosed in one patient and no lymphoid malignancies were observed during the observational period. All patients were alive at the end of follow-up, except one who died of cardiovascular disease, 7 months after graft loss.
Conclusions: These results indicate that ATG-F induction in pediatric kidney transplantation using deceased donor kidneys is associated with good graft and patient survival rates, and with low levels of complications.

Keywords: pediatric renal transplantation, Deceased Donor, Immunosuppression

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358