Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

22 December 2010

Significance of in situ hybridization results for EBV-encoded RNA in post-transplantation lymphoproliferative disorder setting: Report from the PTLD.Int Survey

Morteza Izadi, Saeed Taheri

Ann Transplant 2010; 15(4): 102-109 :: ID: 881358


ABSTRACT: Background: Epstein–Barr virus (EBV) encodes 2 small nonpolyadenylated noncoding RNAs termed EBERs. EBERs are the most common viral transcripts found in EBV-infected cells. In the present study we aimed to examine various aspects of EBER positivity in PTLD patients. Material/Methods: We conducted a comprehensive search for the available data by Pubmed and Google Scholar search engines for reports indicating results of EBERs in PTLD patients. Data from 27 previously published studies were included into analysis. Finally, 243 recipients of allograft were included into analysis. Results: One and 5 years survival rates for PTLD patients with EBER-positive results were 61% and 50%, respectively, compared to 55% and 49%, respectively, for EBER-negative PTLD patients. When death specifically due to PTLD was used as the final outcome, EBER-positive PTLD patients had relatively superior outcome; although p-value did not reach the significance level (p=0.09). EBER-positive patients were significantly more likely to develop PTLD lesions of B cell types (vs. T cell type; p=0.018); and early onset PTLD (p<0.001). EBER-positive PTLD patients were significantly more likely to be polymorphic versus monomorphic (p=0.05). EBER-negative PTLD patients were more likely to develop non-Hodgkin PTLD lesions (p<0.001). Conclusions: We found that PTLD patients with positive results for EBER represent relatively better histopathological features than those in EBER-negative PTLD patients, and the survival rate of EBER-positive PTLD patients is not inferior to that of the EBER-negative subjects. Moreover, they were more likely to represent early onset PTLD of B cell type with polymorphic and Hodgkin-like lesions; and biopsy specimens from different organs were significantly different regarding EBER test results. Future studies with large PTLD populations are needed to confirm our findings.

Keywords: post transplant lymphoproliferative disorders, EBV-Encoded RNA, EBER, in situ hybridization, PTLD


In Press

04 Aug 2022 : Original article  

Long-Term Patency of All-in-One Sleeve Patch Graft Venoplasty in 16 Patients Who Underwent Living Donor Liv...

Ann Transplant In Press; DOI: 10.12659/AOT.936888  

22 Jul 2022 : Original article  

Diagnostic Role of Tumor Markers for Hepatocellular Carcinoma in Liver Transplantation Candidates: An Analy...

Ann Transplant In Press; DOI: 10.12659/AOT.936937  

22 Jul 2022 : Original article  

Development of a Novel Model for Predicting Postoperative Short-Term Outcome in Patients with Hepatitis B-R...

Ann Transplant In Press; DOI: 10.12659/AOT.936732  

22 Jul 2022 : Original article  

Leucine-Rich Alpha-2-Glycoprotein (LRG-1) as a Potential Kidney Injury Marker in Kidney Transplant Recipients

Ann Transplant In Press; DOI: 10.12659/AOT.936751  

Most Viewed Current Articles

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

24 Jul 2020 : Review article  

Kidney Transplantation in the Times of COVID-19 – A Literature Review

DOI :10.12659/AOT.925755

Ann Transplant 2020; 25:e925755

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358