Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

23 March 2011

Left ventricular assist device as ‘bridge to weight loss’ prior to transplantation in obese patients with advanced heart failure

Pavittarpaul DhesiABCDEF, Sinan A. SimsirAE, Daniel DaneshvarBC, Asim RafiqueBC, Anita PhanADEF, Ernst R. SchwarzADEF

Ann Transplant 2011; 16(1): 5-13 :: ID: 881632


Background: Obesity is a risk factor for heart failure (HF) and associated with poor outcomes after cardiac transplantation.
We assessed change in total body weight, morbidity and mortality in obese heart failure patients after implantation of a left ventricular assist device (LVAD) compared to medical management.
Material/Methods: Nineteen patients (9 females, age 51.3±10 years) with a body mass index (BMI) ≥30.0 kg/m2 and advanced HF (NYHA class III–IV, stage D) were evaluated. Thirteen (group 1) received insertion of a LVAD as bridge to transplantation. The remaining patients (group 2) were medically managed. All were advised on lifestyle modification.
Results: At baseline, group 1 (49.1±10.7 years) had a total body weight (BW) of 246.6±34.9 pounds (mean ±SD) and a BMI of 36.1±4 kg/m2. Group 2 (56±6.7 yrs) had a BW of 238.8±73.6 pounds and a BMI of 39.1±9.3 kg/m2 (n.s. compared to group 1). All patients were alive at 12 months. At 6 months, BW in group 1 was reduced to 216.3±20.8 pounds, and BMI to 31.8±3.3 kg/m2 (p<0.05). At 6 months, BW in group 2 was 238.2±84.6 pounds, and BMI was 39.1±11.6 kg/m2 (n.s. vs. baseline, p<0.05 compared to group 1). The decrease in BW in group 1 was 12.3±12% (30.3±28.5 pounds). There was no change in BW in group 2 (0.3±8.7%, 0.6±21 pounds, p<0.05 vs. group 1). At 12 months, 7 patients in group 1 (54%) underwent cardiac transplantation.
Conclusions: LVAD insertion resulted in weight loss in obese patients not considered for heart transplantation compared to medically managed patients.

Keywords: left ventricular assist device, Heart Failure, obesity, Weight Loss, cardiac transplantation

Add Comment 0 Comments

495 23

In Press

02 Jun 2023 : Original article  

Survival analysis of transplant-associated thrombotic microangiopathy under different diagnostic criteria a...

Ann Transplant In Press; DOI: 10.12659/AOT.939890  

17 May 2023 : Original article  

Results of Liver Retransplantation After Rescue Hepatectomy: A Single-Center Study

Ann Transplant In Press; DOI: 10.12659/AOT.939557  

10 May 2023 : Original article  

Incidence of Thromboembolic Complications Following Kidney Transplantation with Short and Extended Aspirin ...

Ann Transplant In Press; DOI: 10.12659/AOT.939143  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358