Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

23 March 2011

Features, predictors and prognosis of lymphoproliferative disorders post-liver transplantation regarding disease presentation time: Report from the PTLD.Int. survey

Morteza Izadi, Saeed Taheri

Ann Transplant 2011; 16(1): 39-47 :: ID: 881637

Abstract

Background: The present study deals with different aspects of PTLD in a very large number of liver transplant recipients, whose data recruited from 30 previous reports, with regard to their presentation time.
Material/Methods: We conducted a comprehensive search for the available data by Pubmed and Google scholar search engines for reports indicating presentation time in PTLD patients. Data from 30 previously published studies were included into analysis. Finally, 231 recipients of liver allograft were included into analysis.
Results: Recipients with early onset PTLD were significantly more likely to represent EBV positive test results (p=0.0003). Recipients with late onset PTLD represented a significantly higher risk of disseminated disease (p=0.049). Late onset PTLD more frequently represented monomorphic lesions (p=0.005). Hodgkin and Hodgkin like diseases also had a trend to occur in the late period after transplantation (p=0.076), although it did not reach significance level. Liver allograft involvement was more often observed in the early onset PTLD (p<0.0001), while colon involvement in the late onset disease (p=0.04). One and five years survival rates for early onset PTLD patients were 64% and 54%, respectively; compared to 73% and 50%, respectively, for the control group (p>0.1).
Conclusions: Due to a higher incidence of liver involvement in the early onset PTLD patients and colon involvement in late onset PTLD, authors suggest that liver graft recipients should receive enough evaluations for a potential multi organ disease based on their presentation time. Further multi-institutional prospective studies are needed to confirm our results.

Keywords: post transplant lymphoproliferative disorders, Liver Transplantation - adverse effects, late onset, early onset

Add Comment 0 Comments

In Press

06 Feb 2024 : Case report  

Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal ...

Ann Transplant In Press; DOI: 10.12659/AOT.941881  

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358