23 March 2011
Post-Transplantation Lymphoproliferative disorders localizing in the adenotonsillar region: Report from the PTLD.Int survey
Hossein KhedmatADEFG, Saeed TaheriABCEFAnn Transplant 2011; 16(1): 109-116 :: ID: 881647
Abstract
Background: The adenotonsillar region is an important localization for post-transplantation lymphoproliferative disorders (PTLD) due to its anatomical relevance. In this study, we sought to aggregate data of PTLD series reported by different international authors on tonsillar and adenoidal localization of PTLD and to compare their data with other PTLD patients. Material/Methods: We conducted a comprehensive search for the available data by Pubmed and Google Scholar search engines for reports of lymphoproliferative disorders occurring within tonsils and adenoids among organ transplant patients. Data from 22 previously published studies from various countries were included into analysis. Results: Overall, 352 patients with lymphoproliferative disorders after organ transplantation were entered into analysis. Patients with adenotonsillar PTLD were significantly younger (13±15 vs. 26±23 yr/o; p<0.0001), more frequently females (56% vs. 35%; p=0.013), less likely to develop metastasis (4.5% vs. 12.5%; p=0.07), and were more frequently from polyclonal (80% vs. 53%; p=0.002) and polymorphic (68% vs. 27%; p=0.001) histopathologic features. Adenotonsillar PTLD also had a significantly superior survival than other PTLD localizations during the first 4 year after diagnosis (p=0.031). Five-year survival rates for adenotonsillar PTLD and other PTLD localizations were 54% and 39%, respectively. Conclusions: We found that adenotonsillar localization by PTLD is a relatively benign disease with respect to its histological features and survival compared to other sites of PTLD involvement. Adenotonsillar PTLD is more prevalent in younger patients, females and liver transplant recipients. Therefore, to enhance early detection and treatment, we seek to alert doctors about any adenotonsillar symptoms in pediatric transplant recipients.
Keywords: post transplant lymphoproliferative disorders, PTLD, adenotonsillar hypertrophy, localization of neoplasm
In Press
Original article
The Long-Acting Glucagon-Like Peptide-2 Analog Apraglutide Enhances Intestinal Protection and Survival Afte...Ann Transplant In Press; DOI: 10.12659/AOT.945249
Original article
Biopsychosocial Effects of Donor Traits on Heart Transplant RecipientsAnn Transplant In Press; DOI:
Clinical Research
Ten-Year Retrospective Analysis of Continuous Renal Replacement Therapy in Burn Patients: Impact on Surviva...Ann Transplant In Press; DOI:
Original article
Factors Influencing Stress Disorders in Intensive Care Unit (ICU) Patients After Liver Transplantation: A C...Ann Transplant In Press; DOI: 10.12659/AOT.944320
Most Viewed Current Articles
05 Apr 2022 : Original article 13,099
Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver TransplantationDOI :10.12659/AOT.935604
Ann Transplant 2022; 27:e935604
22 Nov 2022 : Original article 10,248
Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...DOI :10.12659/AOT.937988
Ann Transplant 2022; 27:e937988
12 Jan 2022 : Original article 9,598
Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...DOI :10.12659/AOT.934738
Ann Transplant 2022; 27:e934738
15 Mar 2022 : Case report 7,261
Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...DOI :10.12659/AOT.935860
Ann Transplant 2022; 27:e935860