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30 June 2011

Biliary strictures after liver transplantation: Is percutaneous treatment indicated?

Tullio PiardiADE, Michael GregetEF, Maxim AudetB, GianFranco CalandraB, Federico GhezaBC, Bernard ElleroF, Marrie-Lorraine Woehl-JaegleF, Massimiliano CantuC, Nazario PortolaniD, Philippe WolfAF, Patrick PessauxAEF

Ann Transplant 2011; 16(2): 5-13 :: ID: 881858

Abstract

Background: Biliary complications are common after orthotopic liver transplantation. Our study’s aim is to evaluate the efficacy of percutaneous treatment of biliary strictures after orthotopic liver transplantation (OLT).
Material/Methods: Sixty-five patients with biliary anastomotic strictures received percutaneous transhepatic balloon cholangioplasty (PTBC). Three dilatations were performed with a 2- to 4-week period between the procedures. Primary and secondary patency were evaluated, with a follow-up between 6 months and 6 years.
Results: PTBC successfully treated strictures in 52.3% (34/65) of cases. The normalization of clinical and biological features was noted at 2.3 months on average. Neither intercurrent episodes of sepsis nor a worsening of liver function were noted during the treatment; a significant complication was recorded in 8 patients. No patient needed surgery for the treatment of complications after PTBC.
Factors related to a successful PTBC included older age at transplantation and single-site stricture. There were 7 recurrent strictures after PTBC, all successfully treated by nonsurgical procedures. The number of dilatations performed affected both the likelihood of success and the long-term risk of stricture recurrence. Of the 31 PTBC failures, 19 underwent subsequent surgical revision, 8 were treated endoscopically, and 4 were re-transplanted. Multifocal stenoses, central hepatic duct involvement, and intrahepatic localization resulted associated with treatment failure.
Conclusions: PTBC should be considered as a first choice option for treatment of biliary strictures after liver transplantation as well as endoscopic treatment. For solitary extrahepatic strictures that fail PTBC and ERCP, surgical revision provides good results.

Keywords: Liver Transplantation, biliary strictures, percutaneous management, postoperative complication

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358