Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

30 June 2011

The occurrence of postreperfusion syndrome in orthotopic liver transplantation and its significance in terms of complications and short-term survival

Barbara BukowickaABCDEF, Rami Abi AkarABDEF, Anna OlszewskaABDEF, Piotr SmoterADEF, Marek KrawczykADE

Ann Transplant 2011; 16(2): 26-30 :: ID: 881861

Abstract

Background: Postreperfusion syndrome (PRS) is a state of significant hemodynamic instability following graft reperfusion during orthotopic liver transplantation (OLTx). We aimed to investigate its risk factors and influence on patient outcome based on a single centre’s experience.
Material/Methods: A retrospective study on a group of 340 patients undergoing OLTx during the period 2005–2008 was conducted. Piggy-back technique was employed in 266 cases and classical technique in 64. PRS was defined as a decrease in mean arterial pressure greater than 30% below the baseline for a minimum of 1 minute during first 5 minutes of the reperfusion. Logistic regression analysis, Mann-Whitney test and 2-sample proportion test were used. P<0.05 was considered statistically significant.
Results: PRS occurred in 12.1% of patients. We observed correlations between PRS and the following: longer cold ischemia time, operation with classical technique, longer duration of the operation, higher intraoperative erythrocytal mass (EM) and fresh frozen plasma (FFP) requirements, more frequent early post-operative complications, and lower 1-year survival. Retransplantation was needed nearly twice as often in the PRS-group, but the correlation was not statistically significant (the group was very small, as only 8 patients requested re-OLTx). The study did not demonstrate any statistically significant relationship between PRS and donors’ age, recipients’ age or sex, duration of the hospitalization, and occurrence of complications after discharge.
Conclusions: PRS occurrence seems to be associated with higher mortality rate and worse patient outcome. The study revealed a few risk factors that could be relevant in the prevention of PRS.

Keywords: postreperfusion syndrome, Hepatic transplantation, cold ischemia, piggyback technique

Add Comment 0 Comments

In Press

Original article  

Steroid Use in ABO-Incompatible Kidney Transplants: Withdrawal vs Maintenance

Ann Transplant In Press; DOI: 10.12659/AOT.947747  

Original article  

Intra-Arterial Contrast-Enhanced Ultrasound for Transcatheter Thrombolysis in Post-Transplant Hepatic Arter...

Ann Transplant In Press; DOI: 10.12659/AOT.947500  

Original article  

Early Atropine Protocol Enhances Dobutamine Stress Echocardiography in End-Stage Liver Disease: A Practical...

Ann Transplant In Press; DOI: 10.12659/AOT.950166  

Most Viewed Current Articles

15 Aug 2023 : Review article   7,349

Free-Circulating Nucleic Acids as Biomarkers in Patients After Solid Organ Transplantation

DOI :10.12659/AOT.939750

Ann Transplant 2023; 28:e939750

03 Jan 2023 : Original article   7,205

Impact of Autologous Stem Cell Transplantation on Primary Central Nervous System Lymphoma in First-Line and...

DOI :10.12659/AOT.938467

Ann Transplant 2023; 28:e938467

16 May 2023 : Original article   7,029

Breaking Antimicrobial Resistance: High-Dose Amoxicillin with Clavulanic Acid for Urinary Tract Infections ...

DOI :10.12659/AOT.939258

Ann Transplant 2023; 28:e939258

28 May 2024 : Original article   6,629

Effect of Dexmedetomidine Combined with Remifentanil on Emergence Agitation During Awakening from Sevoflura...

DOI :10.12659/AOT.943281

Ann Transplant 2024; 29:e943281

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358