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30 June 2011

The occurrence of postreperfusion syndrome in orthotopic liver transplantation and its significance in terms of complications and short-term survival

Barbara BukowickaABCDEF, Rami Abi AkarABDEF, Anna OlszewskaABDEF, Piotr SmoterADEF, Marek KrawczykADE

Ann Transplant 2011; 16(2): 26-30 :: ID: 881861

Abstract

Background: Postreperfusion syndrome (PRS) is a state of significant hemodynamic instability following graft reperfusion during orthotopic liver transplantation (OLTx). We aimed to investigate its risk factors and influence on patient outcome based on a single centre’s experience.
Material/Methods: A retrospective study on a group of 340 patients undergoing OLTx during the period 2005–2008 was conducted. Piggy-back technique was employed in 266 cases and classical technique in 64. PRS was defined as a decrease in mean arterial pressure greater than 30% below the baseline for a minimum of 1 minute during first 5 minutes of the reperfusion. Logistic regression analysis, Mann-Whitney test and 2-sample proportion test were used. P<0.05 was considered statistically significant.
Results: PRS occurred in 12.1% of patients. We observed correlations between PRS and the following: longer cold ischemia time, operation with classical technique, longer duration of the operation, higher intraoperative erythrocytal mass (EM) and fresh frozen plasma (FFP) requirements, more frequent early post-operative complications, and lower 1-year survival. Retransplantation was needed nearly twice as often in the PRS-group, but the correlation was not statistically significant (the group was very small, as only 8 patients requested re-OLTx). The study did not demonstrate any statistically significant relationship between PRS and donors’ age, recipients’ age or sex, duration of the hospitalization, and occurrence of complications after discharge.
Conclusions: PRS occurrence seems to be associated with higher mortality rate and worse patient outcome. The study revealed a few risk factors that could be relevant in the prevention of PRS.

Keywords: postreperfusion syndrome, Hepatic transplantation, cold ischemia, piggyback technique

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358