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30 September 2011

Two decades of experience in Mucormycosis after kidney transplantation

Behzad EinollahiABCDEF, Mahboob Lessan-PezeshkiB, Jafar AslaniB, Eghlim NematiB, Zohreh RostamiABCD, Mohammad Javad HosseiniB, Mohammad Hassan GhadianiB, Pedram AhmadpourB, Heshmatollah ShahbazianB, Fatemeh Pour-Reza-GholiB, Mohammad Reza GhanjiB, Ammir Hossein MiladipourB, Nader Nouri-MajalanB

Ann Transplant 2011; 16(3): 44-48 :: ID: 881994

Abstract

Background: Invasive mucormycosis is a very rare infection after kidney transplantation. Here, we report 25 renal transplant recipients with mucormycosis; to our knowledge, this is the largest reported population of mucormycosis in these patients.
Material/Methods: In a retrospective study, we collected all kidney transplants with mucormycosis from 9 Transplant Centers of Iran from 1990 to 2010. The definitive diagnosis of mucormycosis was established by obtaining a biopsy specimen of the involved tissue.
Results: The most form of disease was rhino-cerebral (n =13), followed by pulmonary (n=7). Overall mortality rate was 52% (n=13), particularly in recipients with pulmonary infection (100%); however, the mortality rate in rhino-cerebral form of disease was low (30.8%). There was no statistically significant difference in mortality rate between male and female (P=0.8). In addition, no significant differences were seen in mortality rate with age of patients (p=0.8) and time of diagnosis since transplantation (p=0.3). Pulmonary infection was more seen in recipients received azathioprine compared to those on mycophenolate mofetil (p=0.006).
Conclusions: Mucormycosis after renal transplantation has a poor prognosis, particularly patients with pulmonary involvement.

Keywords: mucormycosis, Kidney Transplantation, Infection

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358