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30 September 2011

Ezetimibe in sirolimus-associated hyperlipidemia: To add or not to add to statins?

Mariusz NiemczykABDEF, Leszek PaczekADEF

Ann Transplant 2011; 16(3): 132-134 :: ID: 882006

Abstract

Background: Hyperlipidemia is a universal adverse effect of proliferation signal inhibitors (PSI). We report our experience with ezetimibe/statin combined therapy in a case of a kidney transplant recipient receiving sirolimus (SRL)-based immunosuppression. We also present our doubts concerning the need for ezetimibe in kidney transplant recipients on PSI-based immunosuppression.
Case Report: Results. In the reported patient, ezetimibe/statin combination therapy successfully decreased cholesterol level.
Conclusions: Combined therapy with ezetimibe and statin seems to be effective and safe in transplant recipients with SRL-associated hyperlipidemia. However, well-designed clinical trials should be performed to evaluate if there is an impact of such treatment on the frequency of cardiovascular events and patient survival.

Keywords: Sirolimus - adverse effects, Kidney Transplantation, hyperlipidaemia, ezetimibe treatment

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358