Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

31 March 2012

Results of liver transplantation in the treatment of Budd-Chiari syndrome

Anna MackiewiczBEF, Marcin KotulskiCEF, Krzysztof ZieniewiczAD, Marek KrawczykA

DOI: 10.12659/AOT.882630

Ann Transplant 2012; 17(1): 5-10

Abstract

Background: Budd-Chiari syndrome (BCS) is a rare disorder which can lead to liver failure. It arises from an occlusion of small vessels and/or thrombosis of the major hepatic veins. Polycythemia vera is believed to be one of the most common factors causing BCS. In cases not responding to other measures, liver transplantation may be a successful method of radical treatment.
The purpose of this study was to assess the value and results of liver transplantation in the treatment of Budd-Chiari syndrome.
Material/Methods: This retrospective study included all the cases of LTx (liver transplantation) performed because of BCS in the Department of General, Transplant and Liver Surgery, Medical University of Warsaw and it covered the period from 2000 to 2009. Twenty-four patients (8 men, 16 women) with the average age of 33±11 presented with BCS, 6 patients (25%) underwent previous surgical therapy, 2 patients were treated by mesocaval “H” anastomosis (portosystemic shunts) and 4 patients received TIPSS (transjugular intrahepatic portosystemic shunt) prior to LTx. Polycythemia vera was an underlying risk factor in 11 cases. Two patients needed early retransplantation (re-LTx). In immunosuppressive therapy, schema with glucocorticosteroids and FK-506 predominated.
Results: Four cases of bleeding to peritoneal cavity requiring surgical intervention were observed; 3 patients died in the early post-transplant period due to multiorgan failure and 1 late death occurred because of internal causes. Actual survival rate was 83% at 5 years.
Conclusions: In the late stage, Budd-Chiari syndrome should be considered as an indication for liver transplantation, especially when other measures such as porto-systemic shunts are scarce and ineffective.

Keywords: Transjugular intrahepatic portosystemic shunt (TIPSS), Liver Transplantation, Budd-Chiari syndrome, Liver failure

Add Comment 0 Comments

In Press

06 Feb 2024 : Case report  

Successful Sequential Liver and Isolated Intestine Transplantation for Mitochondrial Neurogastrointestinal ...

Ann Transplant In Press; DOI: 10.12659/AOT.941881  

12 Feb 2024 : Original article  

No Prognostic Impact of Graft-to-Recipient Weight Ratio on Hepatocellular Carcinoma Recurrence Following Li...

Ann Transplant In Press; DOI: 10.12659/AOT.942767  

21 Feb 2024 : Original article  

Use of LCP-Tacrolimus (LCPT) in Kidney Transplantation: A Delphi Consensus Survey of Expert Clinicians

Ann Transplant In Press; DOI: 10.12659/AOT.943498  

Most Viewed Current Articles

05 Apr 2022 : Original article  

Impact of Statins on Hepatocellular Carcinoma Recurrence After Living-Donor Liver Transplantation

DOI :10.12659/AOT.935604

Ann Transplant 2022; 27:e935604

12 Jan 2022 : Original article  

Risk Factors for Developing BK Virus-Associated Nephropathy: A Single-Center Retrospective Cohort Study of ...

DOI :10.12659/AOT.934738

Ann Transplant 2022; 27:e934738

22 Nov 2022 : Original article  

Long-Term Effects of Everolimus-Facilitated Tacrolimus Reduction in Living-Donor Liver Transplant Recipient...

DOI :10.12659/AOT.937988

Ann Transplant 2022; 27:e937988

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358