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31 March 2012

Pharmacokinetic monitoring of mycophenolic acid in heart transplant patients: Correlation the side-effects and rejections with pharmacokinetic parameters

Michał J. FigurskiCE, Tomasz PawińskiAEF, Lee R. GoldbergA, David DeNofrioD, Artur NawrockiC, David O. TaylorB, Kathleen D. LakeB, Donna ChojnowskiB, Leslie M. ShawADEF

DOI: 10.12659/AOT.882638

Ann Transplant 2012; 17(1): 68-78

Abstract

Background: Mycophenolate mofetil is a commonly used immunosuppressant in heart transplantation but pharmacokinetic monitoring is not routinely done. We performed a prospective pilot multi-center trial in de-novo heart transplant recipients to evaluate the pharmacokinetics (PK) of mycophenolic acid (MPA) at multiple time points in the first year following transplant.
Material/Methods: MPA trough and estimated area-under-the-curve (AUC) values were obtained at multiple visits from 21 enrolled patients. We attempted to correlate the side-effects and rejections with PK parameters.
Results: MPA AUC and trough levels increased modestly over 12 months with substantial inter and intra patient variability. Cardiac rejection was associated with low MPA AUC values with a threshold of <36.2 mg×h/L during the first two post-transplant weeks. A threshold of 2-weeks average MPA trough level of 1.43 mg/L provided a sensitivity 82% and a specificity of 60%.
Conclusions: Adequate MPA levels are associated with decreased risk of allograft rejection. For patients with Cyclosporine co-immunosuppression, we propose an MPA trough of 1.4 mg/L and an MPA AUC of 36 mg × h/L as threshold values for dose adjustments. We recommend monitoring MPA levels at 1, 2 and 4 weeks, 6 months, 1 year and whenever an unexplained side-effect or allograft rejection occurs. Additional MPA AUC measurements are recommended when trough levels do not explain the clinical picture.

Keywords: Heart Transplant, Pharmacokinetics, Mycophenolate Mofetil, Rejection, clinical outcome, therapeutic drug monitoring

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358