29 June 2012
Successful liver transplantation with continued dual antiplatelet therapy
Henning Spieker, Christoph Benckert, Markus Quante, Armin Thelen, Gereon Gaebelein, Udo Kaisers, Sven JonasDOI: 10.12659/AOT.883231
Ann Transplant 2012; 17(2): 127-130
Abstract
Background: Liver transplantation in patients with dual antiplatelet therapy is considered high-risk procedure due to possible bleeding complications. However, withdrawal of antiplatelet therapy can lead to major adverse cardiac events such as stent thrombosis and even fatal myocardial infarction.
Case Report: We report on a 61-year-old male patient with nutritive toxic liver cirrhosis who underwent liver transplantation at our hospital in March 2010. Following two strokes he received secondary prophylaxis with aspirin and clopidogrel, which was continued at time of liver transplantation. The transplantation was performed successfully without withdrawal of the antiplatelet therapy. No cardiac event and no major bleeding complication occurred.
Conclusions: This is, to our knowledge, the first report of a liver transplantation under dual antiplatelet therapy with aspirin and clopidogrel. It shows that even major procedures such as liver transplantation, with its associated high risk of surgical bleeding, can be safely performed with an appropriate risk.
Keywords: Dual antiplatelet therapy, major abdominal surgery, peri-operative risk
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