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31 December 2012

Contribution of donor and recipient characteristics to short- and long-term pancreas graft survival

Denise E. HillingABCDEF, Andrzej G. BaranskiABDE, Ada HaasnootB, Paul J.M. van der BoogBDE, Onno T. TerpstraADE, Perla J. Marang-van de MheenACDEF

DOI: 10.12659/AOT.883691

Ann Transplant 2012; 17(4): 28-38

Abstract

Background: Many donor and recipient factors are known to affect pancreas graft survival. However, their relative importance in explaining differences in graft survival is unknown. Purpose of this study was to retrospectively evaluate the impact of donor and recipient factors on pancreas graft survival, and compare their contribution in explaining graft survival differences.
Material/Methods: Patient records of all 170 pancreas transplantations (158 Simultaneous Pancreas-Kidney; 12 Pancreas-after-kidney) in the period 1997–2008 were reviewed retrospectively to assess recipient factors before/during transplantation, and to assess graft survival. Eurotransplant reports were reviewed to assess donor factors.
Results: Death-censored 1-year graft survival was 88.4% and 82.3% at 3 years. Several factors significantly influenced graft survival: female recipient gender (Hazard Ratio (HR) 2.81[1.10–7.14]), enteric graft drainage (HR 2.85[1.15–7.05]), and donor-recipient match on BMI (HR 2.46[1.01–6.02]). None of the donor factors significantly affected survival. Similar results were found for 1-year survival, except for enteric graft drainage and donor-recipient BMI matching. In total, donor factors explained 3.6% and recipient factors 10.0% of the variance in graft survival. Donor factors were more important for 1-year survival (3.1%), but still less important than recipient factors which explained 6.4%.
Conclusions: Recipient factors are more important in explaining differences in pancreas graft survival than donor factors.

Keywords: Graft Survival, donor-related factors, transplant recipients

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358