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31 December 2012

Predictive factors associated with re-exploration for hemostasis in living donor liver transplantation

Shao-Chun WuABCDEF, Chao-Long ChenA, Chih-Hsien WangABE, Chia-Jung HuangABE, Kwok-Wai ChengABCDEF, Tsung-Hsiao ShihABE, Johnson Chia-Shen YangABE, Bruno JawanABCDEF

DOI: 10.12659/AOT.883696

Ann Transplant 2012; 17(4): 64-71

Abstract

Background: After liver transplantation (LT), re-exploration of the abdomen to check for bleeding is sometime required. Our study aimed to identify the predictive factors by analysis of preoperative and intraoperative presentations that may impact the re-exploration for hemostasis.
Material/Methods: We selected 522 consecutive recipients from the Liver Transplant Program database and medical records between January 1, 1994 and December 1, 2009 in our hospital. Demographic data (age, sex, body mass index, weight, MELD score), preoperative laboratory tests (Hb, platelet, albumin, bilirubin, INR, APTT), and intraoperative presentations (ascites and blood loss, crystalloids, 5% albumin infused, blood products used (such as LPRBC, RBC, FFP, platelet, cryoprecipitate), urine output, Hb at end of operation, and anesthesia) were collected for primary comparison. Potential predictors found by univariate comparison at p<0.1 were put into a multiple binary logistic regression model.
Results: Thirty-eight (7.3%) recipients required re-exploration for hemostasis after LDLT; 80% needed re-exploration only once. In univariate analysis, recipients transfused with FFP >10 ml/kg had a 4.2-fold increased risk of re-exploration (p<0.001). Thirteen potential predictors by univariate comparison at p<0.1 were selected into a multiple binary logistic regression. Fresh frozen plasma (FFP) transfused was the sole predictor.
Conclusions: Each elevation of 1ml of transfused FFP per kg is associated with a 1.033-fold increased incidence of re-exploration for hemostasis. Patients transfused with more than 10 ml/kg FFP during LT require more intensive management within 72 hours due to increase risk of postoperative bleeding.

Keywords: liver transplantation, Hemostasis, Hemorrhage, blood loss, Blood transfusion, exploration

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Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358