Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

31 December 2012

Early everolimus-induced pneumonitis in a renal transplant recipient: A case report

Katarzyna SułkowskaBCDEF, Piotr PalczewskiBCDEF, Dorota Miszewska-SzyszkowskaBEF, Magdalena DurlikAD, Marek GołębiowskiACD, Piotr MałkowskiAD

DOI: 10.12659/AOT.883706

Ann Transplant 2012; 17(4): 144-148

Abstract

Background: Everolimus is a derivative of sirolimus, and is considered to be free of the latter’s pulmonary toxicity. Recently, a few cases of everolimus-induced lung injury have been reported. Early recognition of drug-induced lung disease is important because it can be reversed if appropriate therapy is instituted soon after the onset of symptoms.
Case Report: We present the case of an everolimus-induced pneumonitis in a renal transplant recipient, which occurred as early as on the 5th day after everolimus introduction.
Shortly after the transplant procedure, the patient presented with typical symptoms of pulmonary infection. Chest radiography and computed tomography showed bilateral patchy lung infiltrates with peribronchial distribution that were suggestive of bacterial pneumonia. However, there was no improvement with empiric antibiotic treatment. Repeated cultures from the blood, sputum, and broncho-alveolar lavage (BAL) also were negative. Tuberculosis, Pneumocystis jiroveci, and Cytomegalovirus infections were excluded. A transbronchial lung biopsy performed 9 days after the onset of symptoms revealed mild nonspecific inflammation with a fibrotic component in the bronchial walls. Withdrawal of everolimus on the third day of hospitalization and after 8 days of its usage resulted in quick clinical recovery and resolution of radiological abnormalities within 1 month.
Conclusions: Diagnosis of drug-induced pulmonary toxicity is difficult because it is essentially a diagnosis of exclusion. Lack of response to empiric antibiotic treatment and an imaging pattern of organizing pneumonia should raise suspicion of everolimus-induced pneumonitis in patients undergoing therapy with this drug.

Keywords: Everolimus, pneumonitis, Transplantation

0 Comments

SARS-CoV-2/COVID-19

29 March 2023 : Editorial  

Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...

Med Sci Monit In Press; DOI: 10.12659/MSM.940519  

06 December 2022 : Original article  

Changes in Physical Activity Due to Fear of COVID-19 and Its Impact on Depression Among Post-Liver Transpla...

Ann Transplant 2022; 27:e938239

12 April 2022 : Letter/Correspondence  

Pancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas Transpla...

Ann Transplant 2022; 27:e935863

In Press

27 Mar 2023 : Original article  

Outcomes of Kidney Transplantation in Older Recipients

Ann Transplant In Press; DOI: 10.12659/AOT.938692  

27 Mar 2023 : Original article  

The Incidence of Brain-Dead Donors Based on Screening and Management Led by Intensivists

Ann Transplant In Press; DOI: 10.12659/AOT.939521  

22 Mar 2023 : Original article  

Effect of Sodium Bicarbonate Ringer’s Solution on Intraoperative Blood Gas Analysis and Postoperative Recov...

Ann Transplant In Press; DOI: 10.12659/AOT.939097  

17 Mar 2023 : Original article  

Converting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Followi...

Ann Transplant In Press; DOI: 10.12659/AOT.938731  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358