Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

08 March 2013

Correlation between serum YKL-40 (Chitinase-3-like protein 1) level and proteinuria in renal transplant recipients

Erhan TatarABE, Ozkan GungorBE, Aygul CeltikE, Ali Rıza SismanD, Mustafa YaprakB, Gulay AsciC, Mehmet OzkahyaAD, Huseyin TozACD

DOI: 10.12659/AOT.883844

Ann Transplant 2013; 18:94-99


BACKGROUND: YKL-40 (chitinase-3-like protein 1) is a novel inflammation and endothelial dysfunction biomarker. Although YKL-40 is associated with albuminuria and predicts cardiovascular morbidity and mortality in a non-uremic population, it’s status is not known in renal transplant recipients. The aim of this study was to investigate plausible links between serum YKL-40 and proteinuria.

MATERIAL AND METHODS: A total of 110 renal transplant recipients were included in this study. The level of proteinuria was calculated from spot urine using the protein/creatinine ratio. The estimated glomerular filtration rate (GFR) was calculated using the Modification of Diet in Renal Disease (MDRD) formula. Serum YKL-40 was determined by ELISA (R&D Systems, USA).

RESULTS: The mean patient age was 40.5±10 years. The mean YKL-40, GFR, and proteinuria levels were 66±46 ng/ml, 49±24 ml/min/1.73 m2, and 0.77±1.15 g/day, respectively. Increases in the YKL-40 tertiles were correlated with increases in proteinuria and C-reactive protein and decreases in the GFR and serum albumin. An adjusted linear regression analysis demonstrated that the YKL-40 level (t=3.28, P=0.001), GFR (t=–3.00, P=0.003), and systolic blood pressure (t=2.51, P=0.01) were independently associated with proteinuria.

CONCLUSIONS: This is the first study to show that increased serum YKL-40 levels are independently associated with proteinuria in renal transplant recipients. YKL-40 may be responsible for the pathogenesis of cardiovascular injury in this patient population.

Keywords: YKL-40, Proteinuria, C-Reactive Protein, endothelial dysfunction, renal transplantation



29 March 2023 : Editorial  

Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...

Med Sci Monit In Press; DOI: 10.12659/MSM.940519  

06 December 2022 : Original article  

Changes in Physical Activity Due to Fear of COVID-19 and Its Impact on Depression Among Post-Liver Transpla...

Ann Transplant 2022; 27:e938239

12 April 2022 : Letter/Correspondence  

Pancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas Transpla...

Ann Transplant 2022; 27:e935863

In Press

27 Mar 2023 : Original article  

Outcomes of Kidney Transplantation in Older Recipients

Ann Transplant In Press; DOI: 10.12659/AOT.938692  

27 Mar 2023 : Original article  

The Incidence of Brain-Dead Donors Based on Screening and Management Led by Intensivists

Ann Transplant In Press; DOI: 10.12659/AOT.939521  

22 Mar 2023 : Original article  

Effect of Sodium Bicarbonate Ringer’s Solution on Intraoperative Blood Gas Analysis and Postoperative Recov...

Ann Transplant In Press; DOI: 10.12659/AOT.939097  

17 Mar 2023 : Original article  

Converting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Followi...

Ann Transplant In Press; DOI: 10.12659/AOT.938731  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358