Logo Annals of Transplantation Logo Annals of Transplantation Logo Annals of Transplantation

11 March 2013

Long-term outcome of en bloc pediatric kidney transplantation in adult recipients – up to 22 years of center experience

Hildegard Hafner-GiessaufBCDEF, Astrid MauricBD, Helmut MüllerE, Philipp EllerACE, Richard ZigeunerE, Florian IbererBE, Alexander R. RosenkranzDE, Kathrin EllerABCDEF

DOI: 10.12659/AOT.883845

Ann Transplant 2013; 18:100-106


BACKGROUND: Renal transplantation has been shown to be the best therapeutic option in end-stage renal disease patients. En bloc transplantation of pediatric kidneys into adult recipients (EBKT) is one strategy to increase the donor pool. We here report on 10 to 22 years of follow-up (median of 12.8 years) of patients receiving EBKT in a single-center, retrospective cohort study.

MATERIAL AND METHODS: The mean donor age was 14±12 months and mean donor body weight was 8±3 kilograms. Thirteen recipients (6 females, 7 males) were followed for 10 to 22 years. The mean recipient age was 44±13 years at the time of transplantation.

RESULTS: Two of 13 patients lost their grafts in the first week because of hemorrhagic infarction of the kidney transplants or sepsis (septic shock). Only 1 patient had an acute cellular rejection, which was successfully treated with steroids and anti-CD3 antibody. Eleven out of 13 patients after EBKT survived and had a functioning graft 10 to 22 years after successful EBKT. The serum creatinine was 1.34±0.6 mg/dl at 5 years (n=11), 1.37±0.7 mg/dl at 10 years (n=11), 1.40±0.6 mg/dl at 15 years (n=4), and 1.08 mg/dl at 20 years after EBKT (n=2). The eGFR, evaluated by using MDRD-2, was 66.5±22 ml/min/m2 at 5 years (n=11), 62±28 ml/min/m2 at 10 years (n=11), 56±23 ml/min/m2 at 15 years (n=4), and 61 ml/min/m2 at 20 years after EBKT (n=2). Proteinuria did not increase significantly within the observation period.

CONCLUSIONS: In our experience, if the acute post-operative phase is uncomplicated, EBKT has excellent long-term graft and patient survival.

Keywords: Graft Survival, renal transplantation, extended criteria donor, organ deficit



29 March 2023 : Editorial  

Editorial: Effective Direct-Acting Antiviral Treatments Support Global and National Programs to Eliminate H...

Med Sci Monit In Press; DOI: 10.12659/MSM.940519  

06 December 2022 : Original article  

Changes in Physical Activity Due to Fear of COVID-19 and Its Impact on Depression Among Post-Liver Transpla...

Ann Transplant 2022; 27:e938239

12 April 2022 : Letter/Correspondence  

Pancreas Allograft Thrombosis as a Post-COVID-19 Complication in a Diabetic Patient After Pancreas Transpla...

Ann Transplant 2022; 27:e935863

In Press

27 Mar 2023 : Original article  

Outcomes of Kidney Transplantation in Older Recipients

Ann Transplant In Press; DOI: 10.12659/AOT.938692  

27 Mar 2023 : Original article  

The Incidence of Brain-Dead Donors Based on Screening and Management Led by Intensivists

Ann Transplant In Press; DOI: 10.12659/AOT.939521  

22 Mar 2023 : Original article  

Effect of Sodium Bicarbonate Ringer’s Solution on Intraoperative Blood Gas Analysis and Postoperative Recov...

Ann Transplant In Press; DOI: 10.12659/AOT.939097  

17 Mar 2023 : Original article  

Converting from Tenofovir Disoproxil Fumarate to Tenofovir Alafenamide in Patients with Hepatitis B Followi...

Ann Transplant In Press; DOI: 10.12659/AOT.938731  

Most Viewed Current Articles

24 Aug 2021 : Review article  

Normothermic Machine Perfusion (NMP) of the Liver – Current Status and Future Perspectives

DOI :10.12659/AOT.931664

Ann Transplant 2021; 26:e931664

26 Jan 2022 : Review article  

Recurrence of Hepatocellular Carcinoma After Liver Transplantation: Risk Factors and Predictive Models

DOI :10.12659/AOT.934924

Ann Transplant 2022; 27:e934924

29 Dec 2021 : Original article  

Efficacy and Safety of Tacrolimus-Based Maintenance Regimens in De Novo Kidney Transplant Recipients: A Sys...

DOI :10.12659/AOT.933588

Ann Transplant 2021; 26:e933588

15 Mar 2022 : Case report  

Combined Liver, Pancreas-Duodenum, and Kidney Transplantation for Patients with Hepatitis B Cirrhosis, Urem...

DOI :10.12659/AOT.935860

Ann Transplant 2022; 27:e935860

Your Privacy

We use cookies to ensure the functionality of our website, to personalize content and advertising, to provide social media features, and to analyze our traffic. If you allow us to do so, we also inform our social media, advertising and analysis partners about your use of our website, You can decise for yourself which categories you you want to deny or allow. Please note that based on your settings not all functionalities of the site are available. View our privacy policy.

Annals of Transplantation eISSN: 2329-0358
Annals of Transplantation eISSN: 2329-0358